Homework Problems #2 1. Draw the peptide KTQHV, write the sequence using 3-letter abbreviation for the amino acids, and identify: a. The N- and C-termini. b. Every a-carbon of the sequence, by labeling them with "a". c. All peptide bonds. d. Hydrogen bond donors and acceptors in the polar side chains. e. Covalent bonds that correspond to the backbone phi (D) and psi (4) angles f. Ionizable R-groups of amino acids in this sequence (circle them). i. Choose one ionizable group and draw it at pH 1, pH 7, and pH 14 and indicate the approximate net charge at each pH. ii. What fraction of His residues are charged at pH=5.8? 2. Use the table to answer the following questions about the peptide you drew in question 1. Amino PK1 Acid Lys 2.18 8.95 PK2 (-COOH) (NH3) (R-group) 10.53 PKR Thr 2.11 9.62 Gln 2.17 9.13 His 1.82 9.17 6.00 Val 2.32 9.62 a. Determine the net charge of the peptide at pH 0 and 14? b. Estimate the pl for this peptide. Is this an acidic or basic peptide?

Homework Problems #2 1. Draw the peptide KTQHV, write the sequence using 3-letter abbreviation for the amino acids, and identify: a. The N- and C-termini. b. Every a-carbon of the sequence, by labeling them with "a". c. All peptide bonds. d. Hydrogen bond donors and acceptors in the polar side chains. e. Covalent bonds that correspond to the backbone phi (D) and psi (4) angles f. Ionizable R-groups of amino acids in this sequence (circle them). i. Choose one ionizable group and draw it at pH 1, pH 7, and pH 14 and indicate the approximate net charge at each pH. ii. What fraction of His residues are charged at pH=5.8? 2. Use the table to answer the following questions about the peptide you drew in question 1. Amino PK1 Acid Lys 2.18 8.95 PK2 (-COOH) (NH3) (R-group) 10.53 PKR Thr 2.11 9.62 Gln 2.17 9.13 His 1.82 9.17 6.00 Val 2.32 9.62 a. Determine the net charge of the peptide at pH 0 and 14? b. Estimate the pl for this peptide. Is this an acidic or basic peptide?

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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