AgrD AgrB 20 AIP 2020 20 Heterologous AIP 22 aa NH M AgrC COOH P2 P3 agrA agrC D agrB RNAIII AgrA RNAIII ↑ Exotoxins Surface proteins

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
Problem 7CRQ
icon
Related questions
Question

The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.

1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?

2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:

a) What molecule do you recommend for the trial. Why?

b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for? 

3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.

4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.

    1. Mutation 1
    2. Mutation 2

 

AgrD
AgrB
20
AIP
2020
20
Heterologous AIP
22
aa
NH
M
AgrC
COOH
P2 P3
agrA
agrC D agrB RNAIII
AgrA
RNAIII
↑ Exotoxins
Surface proteins
Transcribed Image Text:AgrD AgrB 20 AIP 2020 20 Heterologous AIP 22 aa NH M AgrC COOH P2 P3 agrA agrC D agrB RNAIII AgrA RNAIII ↑ Exotoxins Surface proteins
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Essentials of Pharmacology for Health Professions
Essentials of Pharmacology for Health Professions
Nursing
ISBN:
9781305441620
Author:
WOODROW
Publisher:
Cengage
Principles Of Pharmacology Med Assist
Principles Of Pharmacology Med Assist
Biology
ISBN:
9781337512442
Author:
RICE
Publisher:
Cengage
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781938168130
Author:
Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:
OpenStax College
Body Structures & Functions Updated
Body Structures & Functions Updated
Biology
ISBN:
9780357191606
Author:
Scott
Publisher:
Cengage
Body Structures & Functions
Body Structures & Functions
Biology
ISBN:
9781285695495
Author:
Scott
Publisher:
Cengage
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax