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4. Below is a diagram of two adjacent genes in the E.coli genome. You have a wild type strain, and several mutant strains. Three of the mutants have mutations in different parts of the intergenic region (m1, m2, and m3). Another 2 mutants (om5, and om6) have mutation in some part of the o70 protein. You also have two double mutants, as indicated in the table below. Gene A Wild tyno -40ish m2 m3 ↓↓ -35-10 ↓ ↓ ACCGAMMATOGGT Gene B

4. Below is a diagram of two adjacent genes in the E.coli genome. You have a wild type strain, and several mutant strains. Three of the mutants have mutations in different parts of the intergenic region (m1, m2, and m3). Another 2 mutants (om5, and om6) have mutation in some part of the o70 protein. You also have two double mutants, as indicated in the table below. Gene A Wild tyno -40ish m2 m3 ↓↓ -35-10 ↓ ↓ ACCGAMMATOGGT Gene B

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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4. Below is a diagram of two adjacent genes in the E.coli genome. You have a wild type strain, and several mutant strains. Three of the mutants have mutations in different parts of the intergenic region (m1, m2, and m3). Another 2 mutants (om5, and om6) have mutation in some part of the o70 protein. You also have two double mutants, as indicated in the table below. RNA: Gene A Wild type m1 om6 -40ish m2 m3 ↓↓ -35-10 ↓↓ ACCGAAAATCGGT CCGTTAAAAACGG The below table shows gene expression for each of the strains: a) Give two possibilities for what the m1 site may be important for; one in which the function is on the level of DNA, and one on the level of RNA. DNA: b) Given the mutant phenotype, which of the above do you think is more likely? Explain. Gene B Wild type m1 m2 m3 om5 om6 om5 & m3 om6 & m2 Gene A 100 100 100 100 100 100 100 100 Gene B 100 100 3 2 2 1 55 60 c) The double mutant strain illustrates the phenomenon of second-site suppression (also called "pseudoreversion"). For each strain indicate which domain(s) of sigma could be mutated to result in the phenotype indicated. Explain your answer. om5:
Transcribed Image Text:4. Below is a diagram of two adjacent genes in the E.coli genome. You have a wild type strain, and several mutant strains. Three of the mutants have mutations in different parts of the intergenic region (m1, m2, and m3). Another 2 mutants (om5, and om6) have mutation in some part of the o70 protein. You also have two double mutants, as indicated in the table below. RNA: Gene A Wild type m1 om6 -40ish m2 m3 ↓↓ -35-10 ↓↓ ACCGAAAATCGGT CCGTTAAAAACGG The below table shows gene expression for each of the strains: a) Give two possibilities for what the m1 site may be important for; one in which the function is on the level of DNA, and one on the level of RNA. DNA: b) Given the mutant phenotype, which of the above do you think is more likely? Explain. Gene B Wild type m1 m2 m3 om5 om6 om5 & m3 om6 & m2 Gene A 100 100 100 100 100 100 100 100 Gene B 100 100 3 2 2 1 55 60 c) The double mutant strain illustrates the phenomenon of second-site suppression (also called "pseudoreversion"). For each strain indicate which domain(s) of sigma could be mutated to result in the phenotype indicated. Explain your answer. om5:
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