1. Every time a human cell divides, over 50 new mutations can be found in the daughter cells 2. Mutations can accumulate over the course of successive cell divisions 3. In every new kid, over 50 new mutations can be found when comparing them to their parents 4. Most of the new mutations in gametes are probably silent*, but there's a good chance that one of them might occur in a gene, and alter that gene in such a way as to potentially create a mutation *Note: by 'silent' we mean that the mutation doesn't have the potential to alter phenotype, either because it is not in a gene, or is in a gene but in the middle of an intron, or is in the coding sequence but is a silent substitution, etc., etc. 5. Most new gene mutations (i.e. mutations that occur in genes that alter gene expression, splicing or protein sequence) are recessive
1. Every time a human cell divides, over 50 new mutations can be found in the daughter cells
2. Mutations can accumulate over the course of successive cell divisions
3. In every new kid, over 50 new mutations can be found when comparing them to their parents
4. Most of the new mutations in gametes are probably silent*, but there's a good chance that one of them might occur in a gene, and alter that gene in such a way as to potentially create a mutation
*Note: by 'silent' we mean that the mutation doesn't have the potential to alter
5. Most new gene mutations (i.e. mutations that occur in genes that alter gene expression, splicing or protein sequence) are recessive
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