Biochemistry, The Molecular Basis of Life, 6th Edition
Biochemistry, The Molecular Basis of Life, 6th Edition
6th Edition
ISBN: 9780190259204
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 6, Problem 77TQ
Summary Introduction

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Whether the catalytic –OH group is a strong or a weak nucleophile, when a free water molecule is excluded from an enzyme’s catalytic pocket.

Introduction:

In case of enzyme-catalyzed reactions, a pocket-like structure exists in the enzyme. This structural part of the enzyme is called the catalytic pocket. This region is composed of numerous functional groups, which mediate the enzymatic catalysis. In most cases, water is excluded from this catalytic pocket to create a suitable microenvironment.

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Biochemistry, The Molecular Basis of Life, 6th Edition

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