Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Chapter 29, Problem 29.27AP
Interpretation Introduction

Interpretation:

The major cations found in interstitial fluid have to be given.

Concept Introduction:

Body fluids: About 60% of human body is water and this water occupies in two departments called the intracellular and extracellular compartments.

Intracellular fluid: The fluids inside the cells are known as intracellular fluids. The major cations in intracellular fluids are potassium, sodium and magnesium and the major anions is phosphorus.

Extracellular fluid: The fluids outside the cells and it include mainly plasma and interstitial fluid. The major cations in extracellular fluids are potassium, sodium and magnesium, calcium and the major anions are phosphorus and chloride.

Extracellular fluids include interstitial fluids and plasma. The fluid surrounding the cells is known as interstitial fluid and sodium is the major cation found in interstitial fluid.

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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism  of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help
To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?
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Chapter 29 Solutions

Fundamentals of General, Organic, and Biological Chemistry (8th Edition)

Ch. 29.8 - Prob. 29.6CIAPCh. 29.8 - One of the more advanced blood tests used to...Ch. 29 - Body fluids occupy two different compartments,...Ch. 29 - Prob. 29.7UKCCh. 29 - Prob. 29.8UKCCh. 29 - Prob. 29.9UKCCh. 29 - Prob. 29.10UKCCh. 29 - Prob. 29.11UKCCh. 29 - Prob. 29.12UKCCh. 29 - Prob. 29.13APCh. 29 - Prob. 29.14APCh. 29 - Prob. 29.15APCh. 29 - Prob. 29.16APCh. 29 - Prob. 29.17APCh. 29 - Prob. 29.18APCh. 29 - Prob. 29.19APCh. 29 - Prob. 29.20APCh. 29 - Prob. 29.21APCh. 29 - Prob. 29.22APCh. 29 - Prob. 29.23APCh. 29 - What are the three main types of cells found in...Ch. 29 - Prob. 29.25APCh. 29 - Prob. 29.26APCh. 29 - Prob. 29.27APCh. 29 - Prob. 29.28APCh. 29 - Prob. 29.29APCh. 29 - Prob. 29.30APCh. 29 - Prob. 29.31APCh. 29 - Prob. 29.32APCh. 29 - Prob. 29.33APCh. 29 - Prob. 29.34APCh. 29 - Prob. 29.35APCh. 29 - Prob. 29.36APCh. 29 - Prob. 29.37APCh. 29 - Prob. 29.38APCh. 29 - Prob. 29.39APCh. 29 - Prob. 29.40APCh. 29 - Prob. 29.41APCh. 29 - Prob. 29.42APCh. 29 - What color is deoxyhemoglobin? Why?Ch. 29 - Prob. 29.44APCh. 29 - Prob. 29.45APCh. 29 - Prob. 29.46APCh. 29 - Prob. 29.47APCh. 29 - Prob. 29.48APCh. 29 - Prob. 29.49APCh. 29 - Prob. 29.50APCh. 29 - Prob. 29.51APCh. 29 - Prob. 29.52APCh. 29 - Prob. 29.53APCh. 29 - Prob. 29.54APCh. 29 - Prob. 29.55CPCh. 29 - Prob. 29.56CPCh. 29 - Prob. 29.57CPCh. 29 - How does active transport differ from osmosis?Ch. 29 - Prob. 29.59CPCh. 29 - Prob. 29.60CPCh. 29 - Prob. 29.61CPCh. 29 - Prob. 29.62CPCh. 29 - Have each member of your group choose an energy...Ch. 29 - Prob. 29.64GPCh. 29 - Prob. 29.65GP
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