Organic Chemistry
Organic Chemistry
12th Edition
ISBN: 9781118875766
Author: T. W. Graham Solomons, Craig B. Fryhle, Scott A. Snyder
Publisher: WILEY
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Chapter 24, Problem 13PP

Practice Problem 24.13

The synthesis of a polypeptide containing lysine requires the protection of both amino groups.

(a) Show how you might do this in a synthesis of the dipeptide KI using the ben-zyloxycarbonyl group as a protecting group.

(b) The benzyloxycarbonyl group can also be used to protect the guanidino group, N H | | N H C N H 2 , of arginine. Show a synthesis of the dipeptide RA.

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