The classes of reactions are involved in the cleavage of the Fmoc group with piperidine, leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written. Concept introduction: The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

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Chapter 24, Problem 11PP

Interpretation Introduction

Interpretation:

The classes of reactions are involved in the cleavage of the Fmoc group with piperidine,

leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written.

Concept introduction:

The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

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