The explanation of structural features of a linker, which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid, is to be given. Concept introduction: In solid-phase peptide synthesis (SPPS), peptides are prepared, residue by residue. The peptide is attached to polymer support at one end. The polymer support is insoluble; the by-products, excess reagents, and solvents are rinsed away in between each synthetic step and the polymer support remains intact. The polypeptide is finally cleaved from the polymer support and is purified by HPLC (high-performance liquid chromatography). The Wang resin is used as polymer support for the batch synthesis of peptide acids following the Fmoc- or tert -Bu-protection. It is cleaved by TFA.

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Answer 1

Question

Chapter 24, Problem 15PP

Interpretation Introduction

Interpretation:

The explanation of structural features of a linker, which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid, is to be given.

Concept introduction:

In solid-phase peptide synthesis (SPPS), peptides are prepared, residue by residue. The peptide is attached to polymer support at one end. The polymer support is insoluble; the by-products, excess reagents, and solvents are rinsed away in between each synthetic step and the polymer support remains intact.

The polypeptide is finally cleaved from the polymer support and is purified by HPLC (high-performance liquid chromatography). The Wang resin is used as polymer support for the batch synthesis of peptide acids following the Fmoc- or tert-Bu-protection. It is cleaved by TFA.

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Identify the Functional Groups (FG) in the following molecules. Classify C atoms as tertiary, 30, or quaternary 40. Identify secondary 20 and tertiary, 30 hydrogen atoms. Please provide steps to undertand each labeling.

Answer 2

Question

Chapter 24, Problem 15PP

Interpretation Introduction

Interpretation:

The explanation of structural features of a linker, which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid, is to be given.

Concept introduction:

In solid-phase peptide synthesis (SPPS), peptides are prepared, residue by residue. The peptide is attached to polymer support at one end. The polymer support is insoluble; the by-products, excess reagents, and solvents are rinsed away in between each synthetic step and the polymer support remains intact.

The polypeptide is finally cleaved from the polymer support and is purified by HPLC (high-performance liquid chromatography). The Wang resin is used as polymer support for the batch synthesis of peptide acids following the Fmoc- or tert-Bu-protection. It is cleaved by TFA.

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Check out a sample textbook solution

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Answer 3

Question

Chapter 24, Problem 15PP

Interpretation Introduction

Interpretation:

The explanation of structural features of a linker, which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid, is to be given.

Concept introduction:

In solid-phase peptide synthesis (SPPS), peptides are prepared, residue by residue. The peptide is attached to polymer support at one end. The polymer support is insoluble; the by-products, excess reagents, and solvents are rinsed away in between each synthetic step and the polymer support remains intact.

The polypeptide is finally cleaved from the polymer support and is purified by HPLC (high-performance liquid chromatography). The Wang resin is used as polymer support for the batch synthesis of peptide acids following the Fmoc- or tert-Bu-protection. It is cleaved by TFA.

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Answer 4

Question

Chapter 24, Problem 15PP

Interpretation Introduction

Interpretation:

The explanation of structural features of a linker, which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid, is to be given.

Concept introduction:

In solid-phase peptide synthesis (SPPS), peptides are prepared, residue by residue. The peptide is attached to polymer support at one end. The polymer support is insoluble; the by-products, excess reagents, and solvents are rinsed away in between each synthetic step and the polymer support remains intact.

The polypeptide is finally cleaved from the polymer support and is purified by HPLC (high-performance liquid chromatography). The Wang resin is used as polymer support for the batch synthesis of peptide acids following the Fmoc- or tert-Bu-protection. It is cleaved by TFA.

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Answer 5

Chapter 24, Problem 15PP

Interpretation Introduction

Interpretation:

The explanation of structural features of a linker, which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid, is to be given.

Concept introduction:

In solid-phase peptide synthesis (SPPS), peptides are prepared, residue by residue. The peptide is attached to polymer support at one end. The polymer support is insoluble; the by-products, excess reagents, and solvents are rinsed away in between each synthetic step and the polymer support remains intact.

The polypeptide is finally cleaved from the polymer support and is purified by HPLC (high-performance liquid chromatography). The Wang resin is used as polymer support for the batch synthesis of peptide acids following the Fmoc- or tert-Bu-protection. It is cleaved by TFA.

Answer 6

Chapter 24, Problem 15PP

Interpretation Introduction

Interpretation:

The explanation of structural features of a linker, which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid, is to be given.

Concept introduction:

In solid-phase peptide synthesis (SPPS), peptides are prepared, residue by residue. The peptide is attached to polymer support at one end. The polymer support is insoluble; the by-products, excess reagents, and solvents are rinsed away in between each synthetic step and the polymer support remains intact.

The polypeptide is finally cleaved from the polymer support and is purified by HPLC (high-performance liquid chromatography). The Wang resin is used as polymer support for the batch synthesis of peptide acids following the Fmoc- or tert-Bu-protection. It is cleaved by TFA.

Answer 7

Chapter 24, Problem 15PP

Interpretation Introduction

Interpretation:

The explanation of structural features of a linker, which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid, is to be given.

Concept introduction:

In solid-phase peptide synthesis (SPPS), peptides are prepared, residue by residue. The peptide is attached to polymer support at one end. The polymer support is insoluble; the by-products, excess reagents, and solvents are rinsed away in between each synthetic step and the polymer support remains intact.

The polypeptide is finally cleaved from the polymer support and is purified by HPLC (high-performance liquid chromatography). The Wang resin is used as polymer support for the batch synthesis of peptide acids following the Fmoc- or tert-Bu-protection. It is cleaved by TFA.

Answer 8

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Answer 10

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Answer 11

Ch. 24 - Prob. 1PP Ch. 24 - Practice Problem 24.2 The guanidino group NHNHCNH2...Ch. 24 - Prob. 3PP Ch. 24 - Prob. 4PP Ch. 24 - Prob. 5PP Ch. 24 - Prob. 6PP Ch. 24 - Prob. 7PP Ch. 24 - Practice Problem 24.8 Glutathione is a tripeptide...Ch. 24 - Prob. 9PP Ch. 24 - Prob. 10PP

Solution Summary: The author explains the structural features of a linker which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid.

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Chapter 24 Solutions