Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Textbook Question
Chapter 22, Problem 22.77CP
Why is it important for the cell that the NADH produced when pyruvate is converted to lactate be converted back to NAD+?
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How is the malate shuttle used in the liver to increase the number of ATP
generated from glycolysis? Contrast this with how NADH from glycolysis is dealt
with in the muscle.
Under anaerobic conditions, pyruvate will be converted to lactic acid. Why does this occur?
To convert NADH to NAD* to feed back into glycolysis
To supply the glycolysis reaction glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate with needed electrons in the form of NADH
Because lactic acid can be converted to glucose to feed back into glycolysis
Because lactic acid is needed to resupply glycolysis with electrons
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What is the first cofactor to accept electrons from pyruvate in the Pyruvate dehydrogenase complex?
Thymine pyroposphate
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Chapter 22 Solutions
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Ch. 22.2 - Prob. 22.1PCh. 22.2 - Prob. 22.2PCh. 22.3 - Prob. 22.3PCh. 22.3 - Prob. 22.4PCh. 22.3 - Prob. 22.5PCh. 22.3 - Prob. 22.6KCPCh. 22.4 - Prob. 22.1CIAPCh. 22.4 - Prob. 22.2CIAPCh. 22.4 - Prob. 22.3CIAPCh. 22.4 - Explain the chemical process that leads to...
Ch. 22.4 - Prob. 22.5CIAPCh. 22.4 - Prob. 22.7PCh. 22.4 - Prob. 22.8PCh. 22.5 - In alcoholic fermentation, each mole of pyruvate...Ch. 22.5 - Name three ways humans have exploited the ability...Ch. 22.5 - Pyruvate has three different fates. What are the...Ch. 22.6 - Prob. 22.12PCh. 22.6 - Prob. 22.13PCh. 22.7 - Prob. 22.14PCh. 22.7 - Prob. 22.15PCh. 22.7 - Prob. 22.16KCPCh. 22.7 - Prob. 22.6CIAPCh. 22.7 - Prob. 22.7CIAPCh. 22.7 - Prob. 22.8CIAPCh. 22.8 - Prob. 22.17PCh. 22.8 - Prob. 22.18PCh. 22.9 - Prob. 22.19PCh. 22.9 - Prob. 22.20PCh. 22.9 - Prob. 22.21PCh. 22.9 - Prob. 22.9CIAPCh. 22.9 - Prob. 22.10CIAPCh. 22.9 - Prob. 22.11CIAPCh. 22.9 - Prob. 22.12CIAPCh. 22 - What class of enzymes catalyzes the majority of...Ch. 22 - Prob. 22.23UKCCh. 22 - Prob. 22.24UKCCh. 22 - Prob. 22.25UKCCh. 22 - Classify each enzyme of glycolysis into one of the...Ch. 22 - Prob. 22.27UKCCh. 22 - Name the molecules used for gluconeogenesis. What...Ch. 22 - Prob. 22.31APCh. 22 - Prob. 22.32APCh. 22 - Prob. 22.33APCh. 22 - Prob. 22.34APCh. 22 - Prob. 22.35APCh. 22 - Prob. 22.36APCh. 22 - Prob. 22.37APCh. 22 - Prob. 22.38APCh. 22 - Prob. 22.39APCh. 22 - Prob. 22.40APCh. 22 - Prob. 22.41APCh. 22 - Prob. 22.42APCh. 22 - Prob. 22.43APCh. 22 - Prob. 22.44APCh. 22 - Prob. 22.45APCh. 22 - Review the 10 steps in glycolysis (Figure 22.3)...Ch. 22 - Prob. 22.47APCh. 22 - Prob. 22.49APCh. 22 - Prob. 22.50APCh. 22 - Prob. 22.51APCh. 22 - How many moles of acetyl-CoA are produced by the...Ch. 22 - Prob. 22.53APCh. 22 - Prob. 22.54APCh. 22 - Prob. 22.55APCh. 22 - Prob. 22.56APCh. 22 - Prob. 22.57APCh. 22 - Prob. 22.58APCh. 22 - Prob. 22.59APCh. 22 - Why does glycogenolysis use fewer steps than the...Ch. 22 - Prob. 22.61APCh. 22 - Prob. 22.62APCh. 22 - Prob. 22.63APCh. 22 - Prob. 22.64APCh. 22 - Prob. 22.65APCh. 22 - Prob. 22.66APCh. 22 - Prob. 22.67APCh. 22 - Prob. 22.68APCh. 22 - Why can pyruvate cross the mitochondrial membrane...Ch. 22 - Look at the glycolysis pathway (Figure 22.3). With...Ch. 22 - Prob. 22.71CPCh. 22 - Prob. 22.72CPCh. 22 - Prob. 22.74CPCh. 22 - Prob. 22.75CPCh. 22 - Prob. 22.76CPCh. 22 - Why is it important for the cell that the NADH...Ch. 22 - Prob. 22.78CPCh. 22 - Prob. 22.79CPCh. 22 - Prob. 22.80CPCh. 22 - Prob. 22.81CPCh. 22 - Prob. 22.82GPCh. 22 - Prob. 22.83GPCh. 22 - It is important to avoid air when making wine, so...Ch. 22 - Prob. 22.85GP
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- How come high levels of NADH indicate reduced coenzymes rather than oxidized coenzymes? Isn't pyruvate oxidized by the reduction of NAD+ to NADH? Why is the answer reduced then?arrow_forwardWhich of the following statements about the pentose phosphate pathway (PPP) is true? (A) The purpose of the pentose phosphate pathway is to produce NADH for use in anabolic pathways and ribose 6-phosphate for nucleotide synthesis.(B) The oxidative arm of the PPP produces (2) NADPH per glucose 6-phosphate that enters the pathway. (C) Phosphopentose isomerase converts the ribose 5-phosphate made in the oxidative arm of the PPP into ribulose 5-phosphate that is used to form the ribose sugar of nucleotides.(D) The non-oxidative arm of the PPP interconverts between ribose 5-phosphate and a variety of intermediates of b-oxidation. (E) One of the functions of the PPP is to provide NADPH that inhibits glutathione reductase so that it cannot oxidatively damage RBCs.arrow_forwardDoes high amount of NADPHs inhibit or promote glycolysis and promote or inhibit the Pentose Phosphate PAthway?arrow_forward
- Which of the following conditions is most likely to lead to the activation of pyruvate dehydrogenase? High concentrations of acetyl-CoA High concentrations of NADH High concentrations of NAD+ High concentrations of CO2arrow_forwardIn order to metabolize lactose, most infants express the enzyme lactase in their intestines. How many pyruvate molecules and NADH molecules can be generated in glycolysis from one lactose molecule? Please explain. How many ATP molecules will be used and generated by 1 lactose molecule? Please explain.arrow_forwardWhich one of the following statements about PEP (phosphoenolpyruvate) synthesis is correct? Pyruvate can be converted to PEP by a combination of reactions that use energy from two different types of nucleotide triphosphate Pyruvate can be converted to PEP by pyruvate kinase via a single reaction. Pyruvate can be converted to PEP by a mutase. Pyruvate is converted to PEP by the citric acid cycle.arrow_forward
- Outline malate-aspartate shuttle which aims to bring cytosolic NADH into the mitochondria.arrow_forwardBy the reaction catalyzed by the pyruvate dehydrogenase complex: a) NAD+ is oxidized to become NADH that is used later in the ETC to generate ATPs Ob) NAD+ is reduced to become NADH that is used later in the ETC to generate ATPs c) FAD is oxidized to become FADH2 that is used later in the ETC to generate ATPs O d) FAD is reduced to become FADH2 that is used later in the ETC to generate ATPs e) A and C f) B and Darrow_forwardIf one molecule of fructose-1,6-bisphosphate is converted to pyruvate how many molecules of ATP, NADH, and FADH2 are formed?arrow_forward
- When 1 mole of fructose 1,6-bisphosphate is converted to 2 moles of pyruvate via the glycolysis pathway, the net formation of: *arrow_forwardWhich of the following reactions/ pathways does NOT produce NADH? Payoff phase of glycolysis Oxidative deamination of glutamine β-oxidation of fatty acid Conversion of pyruvate to lactate Conversion of pyruvate to acetyl CoAarrow_forwardWhat is the process that sustains the redox balance of glycolysis under aerobic conditions? transport of lactate from the cell regeneration of NAD* in the citric acid cycle formation of NADH in the reaction of glyceraldehyde 3-phosphate dehydrogenase regeneration of NAD* in fermentation processes regeneration of NAD* in the mitochondrial electron-transport chainarrow_forward
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