(a)
Interpretation:
The structure of the Weinreb amide on completion of the given reaction is to be predicted.
Concept introduction:
The Weinreb amides behave as electrophiles. Therefore, they are reactive in the presence of nucleophiles. Weinreb amides are used as a reducing agent and they are selective in nature which converts amides into
(b)
Interpretation:
The structure of the intermediate formed on reaction between Weinreb amide and Grignard reagent is to be drawn. The two reasons for the stability of intermediate to decomposition is to be explained.
Concept introduction:
Grignard reagents are
(c)
Interpretation:
The curved-arrow mechanism for the break down of tetrahedral intermediate into
Concept introduction:
Grignard reagents are organometallic compounds which are prepared using alkyl halides in the presence of magnesium metal in dry ether. These reagents act as strong nucleophiles and bases. The Grignard reagent is used to increase the chain length of the carbon-carbon bond.
(d)
Interpretation:
The products formed when cyclohexanecarbonyl chloride (A) converted into Weinreb amide (B), which further reacts with propylmagnesium bromide (C) followed by protonolysis are to be stated.
Concept introduction:
Grignard reagents are organometallic compounds which are prepared using alkyl halides in the presence of magnesium metal in dry ether. These reagents act as strong nucleophiles and bases. The Grignard reagent is used to increase the chain length of the carbon-carbon bond.
(e)
Interpretation:
The reason as to why the acid chloride is not reacted with Grignard or oraganolithium reagent instead of using Weinreb amide is to be stated.
Concept introduction:
Grignard reagents are organometallic compounds which are prepared using alkyl halides in the presence of magnesium metal in dry ether. These reagents act as strong nucleophiles and bases. The Grignard reagent is used to increase the chain length of the carbon-carbon bond.
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Chapter 21 Solutions
Organic Chemistry Study Guide and Solutions
- Predict the major products of this organic reaction: 1. NaH (20°C) 2. CH3Br ? Some notes: • Draw only the major product, or products. You can draw them in any arrangement you like. • Be sure to use wedge and dash bonds where necessary, for example to distinguish between major products that are enantiomers. • If there are no products, just check the box under the drawing area. No reaction. Click and drag to start drawing a structure. G Crarrow_forwardPredict the major products of this organic reaction: 1. LDA (-78°C) ? 2. Br Some notes: • Draw only the major product, or products. You can draw them in any arrangement you like. . • Be sure to use wedge and dash bonds where necessary, for example to distinguish between major products that are enantiomers. • If there are no products, just check the box under the drawing area. No reaction. Click and drag to start drawing a structure. Xarrow_forwardPlease draw the structuresarrow_forward
- Draw the missing intermediates 1 and 2, plus the final product 3, of this synthesis: 0 1. Eto 1. Eto- 1 2 2. MeBr 2. EtBr H3O+ A 3 You can draw the three structures in any arrangement you like. Explanation Check Click and drag to start drawing a structure.arrow_forwardDraw the missing intermediate 1 and final product 2 of this synthesis: 1. MeO- H3O+ 1 2 2. PrBr Δ You can draw the two structures in any arrangement you like. Click and drag to start drawing a structure.arrow_forwardWhat is the differences between: Glyceride and phosphoglyceride Wax and Fat Soap and Fatty acid HDL and LDL cholesterol Phospho lipids and sphingosine What are the types of lipids? What are the main lipid components of membrane structures? How could lipids play important rules as signaling molecules and building units? The structure variety of lipids makes them to play significant rules in our body, conclude breifly on this statement.arrow_forward
- What is the differences between DNA and RNA for the following: - structure - function - type What is the meaning of: - replication - transcription - translation show the base pair connection(hydrogen bond) in DNA and RNAarrow_forwardWhat is the IP for a amino acid- give an example what are the types of amino acids What are the structures of proteins The N-Terminal analysis by the Edman method shows saralasin contains sarcosine at the N-terminus. Partial hydrolysis of saralasin with dilute hydrochloric acid yields the following fragments: Try-Val-His Sar-Arg-Val His-Pro-Ala Val- Tyr- Val Arg-Val-Tyr What is the structure of saralasin?arrow_forwardWhat is the IP for a amino acid- give an example what are the types of amino acids What are the structures of proteins The N-Terminal analysis by the Edman method shows saralasin contains sarcosine at the N-terminus. Partial hydrolysis of saralasin with dilute hydrochloric acid yields the following fragments: Try-Val-His Sar-Arg-Val His-Pro-Ala Val- Tyr- Val Arg-Val-Tyr What is the structure of saralasin?arrow_forward
- > aw the missing intermediates 1 and 2, plus the final product 3, of this synthesis: 1. Eto 1. EtO¯ H3O+ 1 2 2. PrBr 2. PrBr Δ You can draw the three structures in any arrangement you like. 3 Click and drag to start drawing a structure. Explanation Check 2025 McGraw Hill LLC. All Rights Reserved. Terms of Use Privacarrow_forwardThere are various factors that affect an equilibrium. Give 3 of these factors and explain using examples andequations how an equilibrium is affected by these factors. Please remember that this is a communication question so that you are communicating your understanding of the factors that affect and equilibrium.arrow_forwardEEZE LETCHUP ID Draw the most likely conjugate base resulting from this acid-base reaction. Include all lone pairs. Ignore inorganic byproducts. Drawing く NaOCH2CH3 :0: :0: 狗arrow_forward
Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning