Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 2, Problem 66TQ
Summary Introduction

To review:

Kidney cysts formation due to malfunctioning in primary cilia.

Introduction:

Primary cilia are appendages found in kidney made up of microtubules. They are extensions of the cells thatreceive signals from the extracellular environment. The single primary cilium is nonmotile structure and serves only the purpose of signaling. Other than this, all the secondary cilia are motile structures.

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Two tetrapeptides were isolated from a possum's sweat glands. These peptides were sequenced using Edman degradation and the following 2 sequences were obtained: Gly-Asp-Ala-Leu  Gly-Asp-Asp-Leu  Can you please help show the titration curve for both of these peptides and calculate the PI?
Two tetrapeptides were isolated from a possum's sweat glands. These peptides were sequenced using Edman degradation and the following 2 sequences were obtained: Gly-Asp-Ala-Leu  Gly-Asp-Asp-Leu  What is the structure of the PTH derivative produced during the last round of amino acid sequencing?
What is the primary sequence of this undecapeptide? Also,   if x-ray crystallography shows a highly stable hairpin turn within the polypeptide, what about the primary sequence explains this structural feature?
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