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As described in this chapter, mothers will pass on a mitochondrial defect on their offspring. In a type of gene therapy, one approach to circumvent this problem is to have two different matrernal contributions, with the nucleus of the female with the defective mitochondria being placed in an enucleated egg derived from a female with normal mitochondria. After fertilization, the resulting offspring would have three parental sources of DNA
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Genetic Analysis: An Integrated Approach (3rd Edition)
- If you expose a culture of human cells (for example,HeLa cells) to 3H-thymidine during S phase, howwould the radioactivity be distributed over a pair ofhomologous chromosomes at metaphase? Would theradioactivity be in (a) one chromatid of one homolog,(b) both chromatids of one homolog, (c) one chromatid each of both homologs, (d) both chromatids ofboth homologs, or (e) some other pattern? Choose thecorrect answer and explain your reasoning.arrow_forwardThe Yellow Fever vector mosquito (Aedes Aegypti) is normally 2n = 8. Please draw the following diagrams and in each of your diagrams label the following (or note the absence of): a) a pair of homologous chromosomes b) a pair of sister chromatids A) A somatic cell in this organism undergoing prophase. B) A germ cell undergoing anaphase II.arrow_forwardAccording to the endosymbiosis theory, mitochondria and chloroplasts are derived from bacteria that took up residence withineukaryotic cells. At one time, prior to being taken up by eukaryoticcells, these bacteria were free-living organisms. However, we cannot take a mitochondrion or chloroplast out of a living eukaryoticcell and get it to survive and replicate on its own. Discuss why not.arrow_forward
- Why is a chromosomal fragment without a centromeresubsequently lost and degraded?arrow_forwardWhat difference exists between the compaction of chromosomes during metaphase versus interphase? Give at least one reason why this difference may be necessary.arrow_forwardA somatic cell has the genotype DdEe. All chromosomes in this organism are metacentric. Show metaphase and the results of mitosis if the D and E locus are linked on the same chromosome in trans configuration. A sexually reproducing organism has the following phenotype DdEeAaTt: The D and E loci are on the same arm of a metacentric chromosome in cis configuration. The A locus is on the long arm of an acrocentric chromosome and the T locus is on a telocentric chromosome. 2.1. What is the haploid number of this organism? 2.2. Using diagrams show a ceii at metaphase of mitosis and show the results of mitosis.arrow_forward
- The oncogenic protein BETA promotes entry into the S phase of the cell cycle. Phosphorylation of BETA at the amino acid Tyr98 causes BETA to be degraded by the proteasome, thus limiting its abundance. A mutation in the codon encoding Tyr98 changes this residue to Cys, which cannot be phosphorylated. What is the best description of this mutant allele?a) antimorphb) hypermorphc) hypomorphd) amorphe) neomorpharrow_forwardLeber hereditary optic neuropathy (LHON) is a human disease that exhibits cytoplasmic inheritance. It is characterized by rapid loss of vision in both eyes, resulting from the death of cells in the optic nerve. A teen loses vision in both eyes and is later diagnosed with LHON. How did this individual most likely inherit the mutant DNA responsible for this condition? O A mitochondrial gene from the father O Any of these are possible O A nuclear gene from the mother O A mitochondrial gene from the mother O A nuclear gene from the fatherarrow_forwardColchicine is a chemical mutagen that inhibits the spindle formation and prevents anaphase, which retains the cell’s single restitution nucleus (doubled chromosome number). Suppose that an onion (2n=16) is subjected to three consecutive rounds of colchicine treatment, what will be the resulting chromosome number of the treated onion?arrow_forward
- researchers have been able to clonemammals by fusing a cell having a diploid nucleus (i.e., a somaticcell) with an egg that has had its nucleus removed.A. With regard to maternal effect genes, would the phenotype ofsuch a cloned animal be determined by the animal that donatedthe egg or by the animal that donated the somatic cell? Explain.B. Would the cloned animal inherit extranuclear traits from theanimal that donated the egg or from the animal that donated thesomatic cell? Explain.C. In what ways would you expect this cloned animal to be similarto or different from the animal that donated the somatic cell? Isit fair to call such an animal a clone of the animal that donatedthe diploid nucleus?arrow_forwardAssume that the Holliday junctions resolve so that there is no crossing over (that is, there is no recombination). For the maternal chromosome list all of the possible base identities at the three positions after the cell repairs any mismatches. Do the same for the paternal chromosome.”arrow_forwardTwo nonhomologous chromosomes have the following segments, where * represents the centromere: *ABCDEFG , *RSTUVWX. Name the type of chromosomal rearrangements that would produce each of the following chromosomes. *ABABCDEFG , *ABCD , GFEDCBA*RSTUVWX , *RSWVUTX , *ABCWX , *RSTUVDEFG . Which of these types of abnormalities are most likely embryonic lethal and which ones are not usually a problem for the individual carrying them? Briefly explain why.arrow_forward
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