Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 17, Problem 26P
Most large protein complexes in mitochondria and chloroplasts are composed both of proteins encoded in the organelle genome and proteins encoded in the nuclear genome. What complexities does this introduce for gene regulation (i.e., for ensuring that the appropriate relative numbers of the proteins in a complex are produced)?
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The GAL gene system in yeast is used to metabolize galactose. In the presence of
galactose, the GAL genes are expressed; however, in the absence of galactose, the
GAL genes are repressed. A yeast mutant is discovered that continuously expresses
the GAL genes in the presence or absence of galactose. Which one of the following
mutations is likely the cause of constitutively expressed GAL genes?
deletion of GAL4
deletion of the UAS elements in the regulatory regions of GAL genes
O deletion of GAL3
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A mutation creates a dominant negative allele of a particular gene. The gene encodes a protein that forms a trimer within the cell. If one or more of the subunits has the mutant structure, the entire trimeric protein is inactive. In a heterozygous cell, if the proteins of both alleles are present at the same levels, what percent of the trimers present in the cell will be active?
A) 100%
B) 5%
C) 50%
D) 33%
E) 5%
7. Progression from metaphase to anaphase in the cell cycle, and subsequent exit from anaphase,
requires sequential events involving the Anaphase Promoting Complex (APC). APC is a multi-
protein complex that has ubiquitin ligase activity (see pp. 611-612 in your textbook re: ubiquitin).
When APC adds adds ubiquitin to a substrate protein, the protein is targeted for degradation by the
proteasome. Two important substrates of APC are the proteins securin and cyclin B. Destruction
of securin allows the separation of sister chromatids at the beginning of anaphase, whereas
subsequent destruction of cyclin B allows cells to exit anaphase (see Figure 24-18 in your
textbook).
APC
Cdh-1
Cdc20-
Securin
Mitotic cyclins
Cohesin
G1
Metaphase
Anaphase
For APC to bind specific substrates, it requires unique adaptor proteins that help it to recognize its
substrates. The adaptor protein Cdc20 allows APC to recognize and ubiquitinate securin, while the adaptor
Cdh-1 allows APC to recognize and…
Chapter 17 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 17 - 17.1 Reciprocal crosses of experimental animals or...Ch. 17 - 17.2 How are some of the characteristics of the...Ch. 17 - 17.3 The human mitochondrial genome encodes...Ch. 17 - What is the evidence that transfer of DNA from the...Ch. 17 - Draw a graph depicting the relative amounts of...Ch. 17 - Prob. 6PCh. 17 - 17.7 What is the evidence that the ancient...Ch. 17 - 17.8 Outline the steps required for a gene...Ch. 17 - 17.9 Consider the phylogenetic tree presented in...Ch. 17 - You are a genetic counselor, and several members...
Ch. 17 - A mutation in Arabidopsis immutans results in the...Ch. 17 - What type or types of inheritance are consistent...Ch. 17 - You have isolated (1) a streptomycin-resistant...Ch. 17 - You have isolated two petite mutants, pet1 and...Ch. 17 - 17.15 Consider this human pedigree for a vision...Ch. 17 - A 50- year - old man has been diagnosed with MELAS...Ch. 17 - 17.17 The first person in a family to exhibit...Ch. 17 - Prob. 18PCh. 17 - 17.19 What is the most likely mode of inheritance...Ch. 17 - 17.20 In , the Russian Tsar Nicholaswas deposed,...Ch. 17 - 17.21 The dodo bird (Raphus cucullatus) lived on...Ch. 17 - Cytoplasmic male sterility (CMS) in plants has...Ch. 17 - 17.23 Wolves and coyotes can interbreed in...Ch. 17 - Prob. 24PCh. 17 - Prob. 25PCh. 17 - Most large protein complexes in mitochondria and...Ch. 17 - As described in this chapter, mothers will pass on...
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