Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 16, Problem 35CTQ
Protein modification can alter gene expression in many ways. Describe how phosphorylation of proteins can alter gene expression.
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Hydrogen bonds are important in DNA replication and transcription. They are relatively weak chemical bonds. Why is this a desirable feature for DNA?
Describe the effect (s) of changing (mutating) the promoter on the transcription of the DNA strand/gene the promoter controls.
What happens to protein synthesis if a nonsense codon is inserted into the gene?
Explain why a point mutation does not necessarily change the original amino acid sequence. (Explain silent mutations)
Choose any pentapeptide composed of five different amino acids. List the amino acids. Present one messenger RNA codon for each amino acids and the sequence of nucleotides on the DNA that originally coded for your pentapeptide.
Genetic expression involves transcription and translation. Match the structure or
molecule to the step
site where amino acid
combines with tRNA
intron sequences are
removed and exons are
combined together
makes RNA more stable in
the cytoplasm
region of DNA with
sequences that combine
with RNA polymerase
transcribed strand that
will go on to translation
connects amino acid to
polypeptide chain and
leaves tRNA
site where tRNA with
amino acid enters the
ribosome
recognized by the protein
synthesis machinery
enzyme that connects
RNA nucleotides to DNA
template
part of tRNA with
nucleotides
complementary to mRNA
1. peptide bond
2.
3.
antisense strand
4. anticodon loop
5. RNA polymerase
5' cap
6. A site
8.
7. splicing
9.
promoter region
acceptor stem
10. poly-A tail
Define mutation. Then describe the three basic types of mutation (substitutions, insertions, and deletions) AND the effects they can each have on the protein(s) for which they code.
Chapter 16 Solutions
Biology 2e
Ch. 16 - Figure 16.5 In E. coli, the tip operon is on by...Ch. 16 - Figure 16.7 In females, one of the two X...Ch. 16 - Figure 16.13 An increase in phosphorylation levels...Ch. 16 - Control of gene expression in eukaryotic cells...Ch. 16 - Post-translational control refers to: regulation...Ch. 16 - How does the regulation of gene expression support...Ch. 16 - If glucose is absent, but so is lactose, the lac...Ch. 16 - Prokaryotic cells lack a nucleus. Therefore, the...Ch. 16 - The a/a operon is an inducible operon that...Ch. 16 - What are epigenetic modifications? the addition of...
Ch. 16 - Which of the following are true of epigenetic...Ch. 16 - The binding of _____ is required for transcription...Ch. 16 - What will result from the binding of a...Ch. 16 - A scientist compares the promoter regions of two...Ch. 16 - Which of the following are involved in post...Ch. 16 - Binding of an RNA binding protein will the...Ch. 16 - An unprocessed pre-mRNA has the following...Ch. 16 - IS. Alternative splicing has been estimated to...Ch. 16 - Post-translational modifications of proteins can...Ch. 16 - A scientist mutates elF-2 to eliminate its GTP...Ch. 16 - Cancer causing genes are called transformation...Ch. 16 - Targeted therapies are used in patients with a set...Ch. 16 - Name two differences between prokaryotic and...Ch. 16 - Describe how controlling gene expression will...Ch. 16 - Describe how transcription in prokaryotic cells...Ch. 16 - What is the difference between a repressible and...Ch. 16 - In cancer cells, alteration to epigenetic...Ch. 16 - A scientific study demonstrated that rat mothering...Ch. 16 - Some autoimmune diseases show a positive...Ch. 16 - A mutation within the promoter region can alter...Ch. 16 - What could happen if a cell had too much of an...Ch. 16 - A scientist identifies a potential transcription...Ch. 16 - Describe how RBPs can prevent miRNAs from...Ch. 16 - How can external stimuli alter...Ch. 16 - Protein modification can alter gene expression in...Ch. 16 - Alternative forms of a protein can be beneficial...Ch. 16 - Changes in epigenetic modifications alter the...Ch. 16 - A scientist discovers a virus encoding a Protein X...Ch. 16 - New drugs are being developed that decrease DNA...Ch. 16 - How can understanding the gene expression pattern...
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- Which of the following are examples of post- translational modification (PTM)? (select two answers) Genomic DNA is methylated by a DNA methyltransferase, altering the binding of transcription factors. Glycogen phosphorylase becomes active when phosphorylated by glycogen phosphorylase kinase. Glucose is phosphorylated by hexokinase as the first step in glycolysis. Ras is active when bound to GTP, and inactive when bound to GDP. Caspase 3 is activated when cleaved by capsase 9.arrow_forwardDefine both transcription and translation. In addition, describe the role(s) of each of the following in the processes of gene expression and protein synthesis: DNA, mRNA, tRNA, rRNA, ribosome(s), RNA polymerase, codon, anticodon, amino acid(s) and polypeptide(s). Be detailed in your answer.arrow_forwardProvide one mechanism by which changes in mRNA levels are not always matched by changes in the protein product of that mRNA.arrow_forward
- Covalent modification of eukaryotic DNA is an important regulator of gene expression. Name one type of covalent modification of DNA. Describe the location of this modification and the effect on gene expression.arrow_forwardADP ribosylation is one example of post-translational modification of an enzyme. Which statements about the process is true? ADP ribosylation will affect protein folding because of the addition of a large molecule ADP ribose can be added to the amine group of lysine or glutamine The ending of DNA around histones in the nucleus is altered by the ADP -ribosylation of the histone proteins in cancer cells ADP ribosylation requires ADP and the target protein as the substrates in the ADP ribosylation ADP ribosylation of phosphoinositol is an important step in signaling through a G protein-coupled receptor pathway.arrow_forwardProtein activity is controlled by multiple mechanisms in the cell. Briefly describe how this type of protein control is used in the cell and if this is an example of pre- or post-translational control. Allosteric activationarrow_forward
- Regulation can occur at many steps in the pathway of gene expression. Briefly describe at least one example of a regulator at the level of: a) transcriptional initiation b) protein stability c) posttranslational protein modificationarrow_forwardExplain point mutations and frameshift mutations. Which is more apt to disrupt the structure and or function of a protein coded for by a gene? Why?arrow_forwardDefine regulatory mutation. Describe how an insertion, deletion, or substituion of a base pair in a promoter might affect the transcription driven by that promoter.arrow_forward
- Explain why a point mutation does not necessarily change the oriignal amino acid sequence. Explain silent mutations.arrow_forwardDiscuss the advantages and disadvantages of genetic regulation at the different points identified.arrow_forwardDetermine whether the following will increase or decrease gene expression: mRNA degradation mRNA capping Binding of a transcriptional activator Ubiquitination of a protein and targeting to the proteasomearrow_forward
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