Chapter 16, Problem 16.52P

Interpretation Introduction

(a)

Interpretation:

Procaine was one of the first local anesthetics. Its hydrochloride salt is marketed as Novocain.

If procaine is chiral or not and if it contains any stereocenter should be identified.

Concept Introduction:

Procaine contains amino ester group, it is a local anesthetic drug. It is required to relief the pain caused by injection of penicillin. It is also required in dentistry. In some regions, procaine is popular as Novocain.

Interpretation Introduction

(b)

Interpretation:

The nitrogen atom of procaine which is a stronger base should be identified.

Concept Introduction:

Procaine contains amino ester group, it is a local anesthetic drug. It is required to relief the pain caused by injection of penicillin. It is also required in dentistry. In some regions, procaine is popular as Novocain.

Interpretation Introduction

(c)

Interpretation:

A structural formula for the salt formed by treating procaine with one mole of HCl, showing which nitrogen is protonated and bears the positive charge should be determined.

Concept Introduction:

Procaine contains amino ester group, it is a local anesthetic drug. It is required to relief the pain caused by injection of penicillin. It is also required in dentistry. In some regions, procaine is popular as Novocain.