GENERAL,ORGANIC, & BIOLOGICAL CHEM-ACCES
4th Edition
ISBN: 9781265982959
Author: SMITH
Publisher: MCG
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Textbook Question
Chapter 11.4, Problem 11.7PP
How many H’s are bonded to each indicated carbon (C1-C8) in the following drugs?
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need help please and thanks dont understand only need help with C-F
Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal…
Please correct answer and don't used hand raiting
need help please and thanks dont understand a-b
Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal energy
Divide the…
Chapter 11 Solutions
GENERAL,ORGANIC, & BIOLOGICAL CHEM-ACCES
Ch. 11.1 - Prob. 11.1PCh. 11.2 - Fill in all H's and lone pairs in each compound.Ch. 11.3 - Prob. 11.2PPCh. 11.3 - Prob. 11.2PCh. 11.3 - Prob. 11.3PCh. 11.3 - Prob. 11.3PPCh. 11.3 - How many lone pairs are present in lidocaine, the...Ch. 11.4 - Convert each compound to a condensed formula.Ch. 11.4 - Convert each condensed formula to a complete...Ch. 11.4 - Convert each skeletal structure to a complete...
Ch. 11.4 - Prob. 11.5PCh. 11.4 - How many H’s are bonded to each indicated carbon...Ch. 11.4 - Using the skeletal structure, determine the...Ch. 11.5 - Prob. 11.7PCh. 11.5 - Prob. 11.8PCh. 11.5 - For each compound. [1] Identify the functional...Ch. 11.5 - How do a carboxylic acid and an alcohol differ?...Ch. 11.5 - Label each of the following condensed structures...Ch. 11.5 - Prob. 11.11PCh. 11.5 - Prob. 11.12PCh. 11.5 - Identify all of the functional groups in atenolol,...Ch. 11.5 - Prob. 11.13PCh. 11.5 - Prob. 11.10PPCh. 11.5 - Prob. 11.14PCh. 11.6 - Indicate the polar bonds in each compound. Label...Ch. 11.6 - Prob. 11.11PPCh. 11.6 - Prob. 11.16PCh. 11.6 - Predict the water solubility of each compound.Ch. 11.6 - Prob. 11.17PCh. 11.7 - Prob. 11.18PCh. 11.7 - Prob. 11.19PCh. 11.7 - Prob. 11.20PCh. 11 - Prob. 21PCh. 11 - Prob. 22PCh. 11 - Complete each structure by filling in all H’s and...Ch. 11 - Complete the structure of mepivacaine by filling...Ch. 11 - Prob. 25PCh. 11 - Prob. 26PCh. 11 - Prob. 27PCh. 11 - Prob. 28PCh. 11 - “Ecstasy” is a widely used illegal stimulant....Ch. 11 - Prob. 30PCh. 11 - Explain why each C—C—C bond angle in benzene...Ch. 11 - Prob. 32PCh. 11 - Convert each compound to a condensed structure.Ch. 11 - Convert each compound to a condensed structure.Ch. 11 - Convert each compound to a skeletal structure.Ch. 11 - Convert each compound to a skeletal structure.Ch. 11 - Convert each shorthand structure to a complete...Ch. 11 - Convert each shorthand structure to a complete...Ch. 11 - Convert each skeletal structure to a complete...Ch. 11 - Convert each skeletal structure to a complete...Ch. 11 - A and B are ball-and-stick models of two compounds...Ch. 11 - Prob. 42PCh. 11 - What is wrong in each of the following shorthand...Ch. 11 - Prob. 44PCh. 11 - Prob. 45PCh. 11 - Albuterol (trade names Proventil and Ventolin) is...Ch. 11 - Prob. 47PCh. 11 - Prob. 48PCh. 11 - Prob. 49PCh. 11 - (a) Identify the functional groups in donepezil,...Ch. 11 - Prob. 51PCh. 11 - GHB is an addictive, illegal recreational drug...Ch. 11 - Prob. 53PCh. 11 - Prob. 54PCh. 11 - Prob. 55PCh. 11 - Prob. 56PCh. 11 - Prob. 57PCh. 11 - (a) Identify the functional groups in venlafaxine,...Ch. 11 - You are given two unlabeled bottles of solids, one...Ch. 11 - State how potassium iodide (KI) and pentane...Ch. 11 - The given beaker contains 100 mL of the organic...Ch. 11 - Prob. 62PCh. 11 - Why do we need to know the shape of a molecule...Ch. 11 - 1,1-Dichloroethylene (CH2=CCl2) is a starting...Ch. 11 - Indicate the polar bonds in each molecule. Label...Ch. 11 - Indicate the polar bonds in each molecule. Label...Ch. 11 - Classify each molecule as polar or nonpolar.Ch. 11 - Classify each molecule as polar or nonpolar. a....Ch. 11 - Which molecule is more water soluble? Explain.Ch. 11 - Explain why pantothenic acid, vitamin B5, is water...Ch. 11 - Prob. 71PCh. 11 - Prob. 72PCh. 11 - Explain why regularly taking a large excess of a...Ch. 11 - You can obtain the minimum daily requirement of...Ch. 11 - Prob. 75PCh. 11 - Vitamin B6 is obtained by eating a diet that...Ch. 11 - Prob. 77PCh. 11 - Can an oxygen-containing organic compound, have...Ch. 11 - Prob. 79PCh. 11 - Prob. 80PCh. 11 - Benzocaine is the active ingredient in topical...Ch. 11 - Methyl salicylate is responsible for the...Ch. 11 - Answer the following questions about aldosterone,...Ch. 11 - Answer the following questions about...Ch. 11 - Prob. 85PCh. 11 - Skin moisturizers come in two types, (a) One type...Ch. 11 - THC is the active component in marijuana (Section...Ch. 11 - Cocaine is a widely abused, addicting drug....
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