Essential Organic Chemistry, Global Edition
Essential Organic Chemistry, Global Edition
3rd Edition
ISBN: 9781292089034
Author: Paula Yurkanis Bruice
Publisher: PEARSON
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Chapter 11, Problem 53P
Interpretation Introduction

Interpretation:

To predict the reagent used for the synthesis of given product from the given reactant.

Concept introduction:

Esterificationis the process in which carboxylic acid reacts with alcohol in the presence of an acid to produce an ester. Carboxylic acid undergoes nucleophilic acyl substitution reaction. The acid protonates the oxygen of carboxylic acid which results in increased electrophilicity of the carbonyl carbon. The alcohol acts as a nucleophile and gets attached to the carbonyl carbon of the carboxylic acid. The unstable tetrahedral intermediate is formed. The hydroxyl group gets eliminated resulting in the formation of an ester.

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Essential Organic Chemistry, Global Edition

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How to Design a Total Synthesis; Author: Chemistry Unleashed;https://www.youtube.com/watch?v=9jRfAJJO7mM;License: Standard YouTube License, CC-BY