Trace the signaling pathway in a liver cell using the information bel When the sympathetic nervous system (SNS) is activated, effects on the breakdown of glycogen into glucose for use by muscle cells and other ti epinephrine are two neurotransmitters of the SNS that bind with alpha-1 surface of liver cells (hepatocytes). These receptors are G-protein coup Protein activates the 2nd messengers Phosholipase C, which in turn prod. PLC does this). The cellular response is an increase in permeability of t (make sure to include which of the second messengers cause this respor Ca2+ binding to calmodulin. Calmodulin then causes the phosphorylatic phosphorylase kinase. This causes an increase of activity for the enzym breaking down glycogen stores. Protein kinase C (PKC) is also activate include which of the second messengers cause this response). PKC cau glycogen synthase, which facilitates glycogen production from glucose.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Question
100%
Trace the signaling pathway in a liver cell using the information below:
When the sympathetic nervous system (SNS) is activated, effects on the liver include an increase in the
breakdown of glycogen into glucose for use by muscle cells and other tissues. Norepinephrine and
epinephrine are two neurotransmitters of the SNS that bind with alpha-1 adrenergic receptors present on the
surface of liver cells (hepatocytes). T
Protein activates the 2nd messengers Phosholipase C, which in turn produces IP3 and DAG (describe how
PLC does this). The cellular response is an increase in permeability of the cell to calcium ions (Ca2")
(make sure to include which of the second messengers cause this response). This causes an increase in
Ca2+ binding to calmodulin. Calmodulin then causes the phosphorylation and activation of glycogen
phosphory lase kinase. This causes an increase of activity for the enzyme glycogen phosphory lase,
breaking down glycogen stores. Protein kinase C (PKC) is also activated in this pathway (make sure to
include which of the second messengers cause this response). PKC causes the inactivation of an enzyme,
glycogen synthase, which facilitates glycogen production from glucose.
hese receptors are G-protein coupled receptors. Once activated, the G
Transcribed Image Text:Trace the signaling pathway in a liver cell using the information below: When the sympathetic nervous system (SNS) is activated, effects on the liver include an increase in the breakdown of glycogen into glucose for use by muscle cells and other tissues. Norepinephrine and epinephrine are two neurotransmitters of the SNS that bind with alpha-1 adrenergic receptors present on the surface of liver cells (hepatocytes). T Protein activates the 2nd messengers Phosholipase C, which in turn produces IP3 and DAG (describe how PLC does this). The cellular response is an increase in permeability of the cell to calcium ions (Ca2") (make sure to include which of the second messengers cause this response). This causes an increase in Ca2+ binding to calmodulin. Calmodulin then causes the phosphorylation and activation of glycogen phosphory lase kinase. This causes an increase of activity for the enzyme glycogen phosphory lase, breaking down glycogen stores. Protein kinase C (PKC) is also activated in this pathway (make sure to include which of the second messengers cause this response). PKC causes the inactivation of an enzyme, glycogen synthase, which facilitates glycogen production from glucose. hese receptors are G-protein coupled receptors. Once activated, the G
Expert Solution
steps

Step by step

Solved in 3 steps with 2 images

Blurred answer
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Anatomy and Physiology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Anatomy & Physiology
Anatomy & Physiology
Anatomy and Physiology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Human Anatomy
Human Anatomy
Anatomy and Physiology
ISBN:
9780135168059
Author:
Marieb, Elaine Nicpon, Brady, Patricia, Mallatt, Jon
Publisher:
Pearson Education, Inc.,
Anatomy & Physiology: An Integrative Approach
Anatomy & Physiology: An Integrative Approach
Anatomy and Physiology
ISBN:
9780078024283
Author:
Michael McKinley Dr., Valerie O'Loughlin, Theresa Bidle
Publisher:
McGraw-Hill Education
Human Anatomy & Physiology (Marieb, Human Anatomy…
Human Anatomy & Physiology (Marieb, Human Anatomy…
Anatomy and Physiology
ISBN:
9780321927040
Author:
Elaine N. Marieb, Katja Hoehn
Publisher:
PEARSON