High [ATP] slows glycolysis and speeds of gluconeogenesis because(check all that apply):Pyruvate kinase is allosterically inhibited by low [ATP]PFK-1 is allosterically inhibited by low [ATP]FBPase-1 is inhibited by high [AMP]FBPase-1 is inhibited by low [AMP]Pyruvate kinase is allosterically inhibited by high [ATP]PFK-1 is allosterically inhibited by high [ATP]

ATP is the energy currency of the cell i.e. the cell mostly uses ATP as the source of energy for…

Answered: High [ATP] slows glycolysis and speeds…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Mutations in adenylate kinase have led to a hyperactive enzyme that ultimately ends up elevating ADP levels in a cell.Calculate the EC (energy charge) given the following atypical adenylate concentrations for the cell containing the mutant adenylate kinase: ATP = 0.5 ??��, ADP = 12.2 ??��, AMP = 80 ??��.
Skeletal muscle myosin heavy chain is a mechanoenzyme that requires ATP for its function. Other enzymes, such as phosphofructokinase-2, also rely on ATP. How are PFK-2 and myosin Il different in their use of ATP? • View Available Hint(s) Both enzymes use ATP in the exact same way. PFK-2 functions as a kinase, whereas myosin functions as a phosphatase. PFK-2 catalyzes ATP hydrolysis, whereas myosin does not. Myosin catalyzes ATP hydrolysis, whereas PFK-2 does not. PFK-2 binds to ATP or ADP + Pj, whereas myosin undergoes covalent modification via phosphorylation. Submit
Which of the following statements about pyruvate kinase expressed in cancer cells is correct? Group of answer choices Cancer cells express the M1 isoform Cancer cells express a less active isoform The isoform in cancer cells is activated by growth factors The isoform in cancer cells produces large quantities of ATP
The rate of the reaction of glycogen N with inorganic phosphate, Pi, to form glucose-1-phosphate and glycogen N-1 is:
In a tumor sample with a mutated fumarate dehydrogenase that is less active than the normal isoform, which of these is not an expected consequence? Group of answer choices Decreased expression of hypoxia-inducible factor alpha Decreased antioxidant response Decreased activation of AMPK Decreased activity of Nrf2
Describe the categories of enzyme control: (image provided) Allosteric control with example Covalent modification with example
Which of the following best describes the use of 2-deoxyglucose in allowing for cancer therapy? Elevates p53 levels directly to regulate glycolytic flux Blocks activation of HIF1transcriptional activation Diminishes lactate production by inhibiting lactate dehydrogenase to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Diminishes lactate export from the cell to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Competes with glucose for hexokinase, allowing inhibition of glycolytic flux, reducing ATP production.
Discuss the metabolic rationale for phosphorylation of acetyl-CoA carboxylase by AMP-activated protein kinase (AMPK) and cyclic AMP–dependent protein kinase (PKA).
select the BEST answer Aconitase is most interesting in that it: Can be coded for by 2 different genes O Exists as either a membrane bound or soluble protein depending on intracellular conditions O Has 2 distinct roles depending on the availability of Iron O Can change the AGº' of it's reaction O Is itself an allosteric regulator of the PDH complex
n your own words and with your own diagrams, describe the catalytic reaction mechanism of the enzyme acetylcholinesterase. Discuss the functional roles of each member of the catalytic triad plus whatever other residues that you find important. Describe the actual movements of protons, and the making and breaking of bonds. What types of chemistries is the enzyme using? (what is the enzyme doing, in term of reaction
Please answer both, thank you
Answer the following questions about the inhibition of acetylcholine esterase by neostigmine. 5a. Does neostigmine have a structure that enables it to bind reversibly to the ACbE active site? 5b. Is neostigmine catalytically processed by ACHE? 5c. How does the stability of the carbamolyl-enzyme intermediate produced by treatment of ACbE with neostigmine compare to the stability of the acetyl- enzyme intermediate produce when ACb, is hydrolyzed?

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