Which of the following best describes the use of 2-deoxyglucose in allowing for cancer therapy? Elevates p53 levels directly to regulate glycolytic flux Blocks activation of HIF1transcriptional activation Diminishes lactate production by inhibiting lactate dehydrogenase to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Diminishes lactate export from the cell to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Competes with glucose for hexokinase, allowing inhibition of glycolytic flux, reducing ATP production.

Which of the following best describes the use of 2-deoxyglucose in allowing for cancer therapy? Elevates p53 levels directly to regulate glycolytic flux Blocks activation of HIF1transcriptional activation Diminishes lactate production by inhibiting lactate dehydrogenase to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Diminishes lactate export from the cell to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Competes with glucose for hexokinase, allowing inhibition of glycolytic flux, reducing ATP production.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter32: The Reception And Transmission Of Extracellular Information

Section: Chapter Questions

Problem 21P

See similar textbooks

Similar questions

Which of the following is an expected effect of HIF-1 regulated release of VEGF? Group of answer choices decreased reliance on oxygen for ATP production increased blood supply to hypoxic regions of tissues increased lactate production increased ATP production by oxidative phosphorylation Which of these is LEAST likely to be present at higher levels as a result of stabilization of HIF-1? Group of answer choices citrate hexokinase lactate dehydrogenase pyruvate dehydrogenase kinase
Which of the following statements about pyruvate kinase expressed in cancer cells is correct? Group of answer choices Cancer cells express the M1 isoform Cancer cells express a less active isoform The isoform in cancer cells is activated by growth factors The isoform in cancer cells produces large quantities of ATP
Each of the following molecules has a role in carcinogenic aerobic glycolysis: c-myc, HIF-1, PKB, and p53. Describe the function of each molecule.
In acute lymphoblastic leukemia, the cancerous white blood cells typically lack the enzyme asparagine synthetase. Why is the administration of asparaginase an eff ective therapy for this type of cancer?
The progressive loss of cardiac myocytes due to cell death has been associated with cardiac dysfunction and heart failure. Which of the following would lead to a significant loss of cardiac myocytes? Select all that apply Treatment of rapamycin which results in inhibition of mTOR activity Prolonged or severe ER stress with increased accumulation of unfolded proteins Activation of AMPK and phosphorylation of the TSC1 complex mTOR activation and phosphorylation of Ulk1
Myostatin is termed a negative growth regulator. Explain themeaning of this term, and describe the consequences of genemutations that cause myostatin to be nonfunctional.
Increased ROS levels are a hallmark for Alzheimer's Disease. This is accurately described by all but which of the following statements? ROS production is upregulated because of the activity of the enzyme NADPH oxidase Oxidative phosphorylation is increased, leading to enhanced ROS generation via the ETC Amyloid precursor protein is converted in higher amounts to the amyloid peptide facilitating greater amounts of aggregation BACE1 levels are transcriptionally increased via hypoxia inducible factor Mitochondrial pyruvate flux is reduced 00000
HbA1c is used to monitor blood glucose levels because hemoglobin is the only protein in blood that is covalently modified by glucose. True False Insulin Glargine is a long-acting form of insulin that is synthesized with several D-amino acids that slow its proteolytic degradation and extend the half-life of the insulin Glargine molecule. True False
Rapid regulation of pyruvate dehydrogenase complex is achieved via which of the following? Transcriptional regulation Covalent modification Allosteric response Degradative control
Autophagy is an évolutionary conserved catabolic process devoted to the degradation of intracellular components. Which of the following would you observe during autophagy? Select all that apply MTOR inhibition through phosphorylation and activation of TSC proteins MTOR activation and phosphorylation of downstream target proteins Increased expression of Rab7 which mediates lysosomal fusion Acute inflammatory response
decrease in cGMP inactivation of a phosphodiesterase activation of guanylyl cyclase increase in cGMP activation of adenylyl cyclase
State the function and desired products of the hexose monophosphate shunt pathway.