Which of the following best describes the use of 2-deoxyglucose in allowing for cancer therapy? Elevates p53 levels directly to regulate glycolytic flux Blocks activation of HIF1transcriptional activation Diminishes lactate production by inhibiting lactate dehydrogenase to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Diminishes lactate export from the cell to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Competes with glucose for hexokinase, allowing inhibition of glycolytic flux, reducing ATP production.

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