Fructose 2,6-bisphosphate allosterically [inhibits/activates] PFK-1 and allosterically [inhibits/activates] FBPase-1.   This is how gluconeogenesis and glycolysis are coordinately regulated.  By deduction, glucagon should [inhibit/activate] the enzyme that produces fructose 2,6-bisphosphate since glucagon [activates/inhibits] gluconeogenesis.

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