rostaglandin-endoperoxide synthase 2, also known as cyclooxygenase- or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. a) Explain how this enzyme facilitates prostaglandin biosynthesis by highlighting two key functions. b) Describe one role for the COX-1 enzyme. c) Name one condition that the selective COX-2 inhibitors Vioxx (Rofecoxib)
rostaglandin-endoperoxide synthase 2, also known as cyclooxygenase- or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. a) Explain how this enzyme facilitates prostaglandin biosynthesis by highlighting two key functions. b) Describe one role for the COX-1 enzyme. c) Name one condition that the selective COX-2 inhibitors Vioxx (Rofecoxib)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:10.
Answer ALL parts of this question.
Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-
2 or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene.
(a) Explain how this enzyme facilitates prostaglandin biosynthesis by
highlighting two key functions.
(b) Describe one role for the COX-1 enzyme.
(c) Name one condition that the selective COX-2 inhibitors Vioxx (Rofecoxib)
and Celebrex (Celecoxib) were used to treat.
(d) Name and draw the chemical structures of 4 other small molecule OCOX-2
inhibitors and identify 3 similarities/common features with respect to
Rofecoxib and Celecoxib.
(e) Name a therapeutic reason for targeting COX-3.
Describe the function and therapeutic utility of non-steroidal anti-
(f)
inflammatory drugs.
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