The Warburg effect is generally observed in cancer cells as a consequence of pyruvate dysmetabolism. Which of the following statements is inaccurate in describing the metabolic switch termed the Warburg effect?   P53 function in regulation of glycolysis is lost, preventing proper cellular response of apoptosis Lactate production becomes the major fate of pyruvate Diminished oxidative phosphorylation in the matrix leads to enhanced non-oxidative ATP production Glycolytic flux is increased Pyruvate levels are diminished through the PDHC Pyruvate carboxylase is activated HIF1transcriptional activation

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A:

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