Explain molecular mechanism of Pi3K signalling and also role of PI kinases and PI phosphatase.
Explain molecular mechanism of Pi3K signalling and also role of PI kinases and PI phosphatase.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Explain molecular mechanism of Pi3K signalling and also role of PI kinases and PI phosphatase.
Expert Solution
Step 1
PI3K:
- It is an intracellular signal transduction pathway that promotes cell proliferation, survival, metabolism, angiogenesis, and growth in response to extracellular signals.
- The important proteins involved in this pathway are phosphatidylinositol 3-kinase (PI3K) and Akt/Protein Kinase B.
- They are a family of intracellular lipid kinases and it consists of two domains: the catalytic domain P110 and the regulatory domain P85.
- The activation of PI3K typically occurs as a result of ligand binding to receptors.
- It can also be activated by a GTP binding RAS protein.
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