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A: Answer : Option "G" is correct - BRCA1
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- Gαq activates which of the following enzymes? a. phospholipase C b. PDK1 c. adenylate cyclase d. PKGWhich of the following drugs would you expect would prevent transformation of cells by the Rous Sarcoma Virus (RSV) (select all that appy)? A. Tyrosine Kinase Inhibitor B. Integrase Inhibitor C. Inhibitor GTPase Activity ✓ D. Reverse Transcriptase Inhibitor E. Staurosporine (inhibitor of Ser/Thr kinases)Which of the following classes of oncogenes would likely be druggable with a small molecule (select all that apply)? A. Nuclear hormone receptor B. RAS C. Serine/Threoine Kinase D. Transcription Factor E. Receptor Tyrosine Kinase
- Which ONE of the following molecular abnormalities is associated with the POOREST prognosis in acute myleoid leukaemia? A. t(8;21) translocaton (RUNX1_RUNX1fusion) B. DNMT3A mutation C. TP53 deletion D. NPM1 mutation.Which inhibitors specifically target CDK4 complexes? A. p57 Kip2 B. p27 Kip1 C. p21 Cip1 D. p16 INK4AOne important role of Fas and Fas ligand is to medi-ate the elimination of tumor cells by killer lymphocytes.In a study of 35 primary lung and colon tumors, half thetumors were found to have amplified and overexpressed agene for a secreted protein that binds to Fas ligand. How doyou suppose that overexpression of this protein might con-tribute to the survival of these tumor cells? Explain yourreasoning.
- Developing B cells that fail to make productive D to J heavy-chain rearrangements on both homologous chromosomes a. die by apoptosis in the bone marrow b. will rearrange heavy-chain loci multiple times until a productive rearrangement is made c. undergo clonal proliferation d. upregulate expression of transcription factors E2A and EBF e. fail to rearrange V to DJ.TGF-B Receptor I (RI) phosphorylation of Smad2/3 does all of the following EXCEPT: activate Smad2/3 binding to the Co-Smad Smad4 dissociate intramolecular binding of Smad2/3 MH1 and MH2 domains. RI phosphorylation of Smad2/3 does all of these things. release Smad2/3 from the nucleus into the cytoplasm unmask the Smad2/3 nuclear localization signal (NLS).A virus has been identified that encodes a protein which inhibits the transporter-associated with antigen processing (TAP). If the virus infects macrophages, the infected cells are most likely to exhibit a reduction in which of the following? Cell surface class I major histocompatibility complex (MHC) proteins O a. b. Cell surface class II major histocompatibility complex (MHC) proteins Ос. Cell surface co-stimulatory proteins O d. Lysosome function е. Proteasome function
- Match the following proteins to their functions ✓ Cathepsins ✓ Calpains ✓ Granzyme B ✓ Apoptosis inducing factor ✓ Apaf-1 • Bax A. Cleaves iCAD, leading to DNA fragmentation B. A component of the apoptosome that results in the activation of pro-caspase 9 C. Activation of caspase 12 in response to increased intracellular Ca2+ D. Homodimers form pores in the outer membrane of the mitochondria E. A mitochondrial flavoprotein that induces chromatin condensation and DNA fragmentation F. Mitochondrial permeability, externalization of phosphatidylserine on the plasma membrane of apoptotic cellsRole of Myc activation is the follows a. It directly inhibits Rb protein through phosphorylation b. It stimulates assembly of S-phase Cdk-cyclin complex c. It stimulates transcription of delayed response genes d. It increases the expression of early response genes Role of Myc activation is the follows a. It directly inhibits Rb protein through phosphorylation b. It stimulates assembly of S-phase Cdk-cyclin complex c. It stimulates transcription of delayed response genes d. It increases the expression of early response genesDefects in this gene have been associated with metastasis in pancreatic cancer. Select one: O a. APC O b. RB O c. p53 O d. C-myc O e. Palladin O f. ras O g. BRCA1