Same question but two different sections Why do transcriptional regulators act as dimers or heterodimers rather than monomers when binding to DNA and regulatinggenes?A. The dimer will interact wtih a greater number of nucleotides compared to the monomer allowing for more specificity wheninteracting with DNA and decreasing the chances of encountering the correct sequence of nucleotides at a random positionwithin the DNA molecule.B. Forming heterodimers means a smaller number of distinct genes can be regulated by a set number of transcriptionalregulators.C. Dimers or heterodimers are required to be able to fit within the minor groove of the DNA helix.D. All of the above. You have the ability to manipulate or change the protein domains contained within the Grb2 protein. What changes would youmake to the domains within Grb2 in order to try and block Ras activation and prevent cell proliferation?A. Add a tyrosine kinase domain.B. Add a PH domain.C. Remove one SH3 domain.D. Remove the SH2 domain.

Answered: Why do transcriptional regulators act…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Same question but two different sections

Why do transcriptional regulators act as dimers or heterodimers rather than monomers when binding to DNA and regulating
genes?
A. The dimer will interact wtih a greater number of nucleotides compared to the monomer allowing for more specificity when
interacting with DNA and decreasing the chances of encountering the correct sequence of nucleotides at a random position
within the DNA molecule.
B. Forming heterodimers means a smaller number of distinct genes can be regulated by a set number of transcriptional
regulators.
C. Dimers or heterodimers are required to be able to fit within the minor groove of the DNA helix.
D. All of the above.

You have the ability to manipulate or change the protein domains contained within the Grb2 protein. What changes would you
make to the domains within Grb2 in order to try and block Ras activation and prevent cell proliferation?
A. Add a tyrosine kinase domain.
B. Add a PH domain.
C. Remove one SH3 domain.
D. Remove the SH2 domain.

Expert Solution

Introduction

Genome of an organism, especially of eukaryotes, contain large number of non-coding sequences. In complex eukaryotes, not all genes are transcribed or expressed in all cell types. This regulation is possible at gene level or DNA level by transcriptional factors.

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