In the experiment below, mice were treated with a virus that inhibited expression of angiopoietin 2, MMP3 and MMP10 in the lung or with a control virus (Mock). Breast cancer cells that express the gene luciferase were then injected into the mammary glands of the mice. The metstasis of the tumors to the lungs could then be measured by imaging the presence of luciferase in the lungs. In 5-6 sentences, explain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis.

Q: The map of the lac operon is shown below. Consider the following examples that include both haploids…

A: Lac operon is the segment of DNA which includes regulatory gene, structural gene, promoter gene and…

Q: Vanessa is a research officer in a laboratory that studies anticancer treatment. She is interested…

A: The maintenance of tissue homeostasis and embryonic development both include the natural…

Q: Gene expression array technology has been used to do which of the following (select all that apply)?…

A: Gene expression array technology is a technology used to measure the expression level of thousands…

Q: Explain one experimental strategy for determining the functional role of the mouse HoxD-3 gene.

A: HoxD-3 gene basically functions in the process of morphogenesis and belongs to the category of…

Q: 12445 RD-Hom 4(167-277) A(194-277) A(97-138) A(97-167) 6 A(97-194) N595A 7890 A(619-723) HD 10…

A: A regulatory protein regulates the expression of a gene by binding with that gene through its DNA…

Q: Suppose you discover a drug that has potential antiviral effect against SARS-CoV2 so you tested its…

A: In microarray, the cDNA of both treated and untreated cells well put together in a well for a…

Q: What are the differences between protein subunit vaccines and mRNA vaccines?”

A: Introduction :  The purpose of vaccines is to boost immunity by artificially introducing weak or…

Q: what do you predict is a likely outcome in mice with the bat-mouse construct? Select one 1.) change…

A: Regulatory "switches" are found upstream from a gene. Regulatory molecules bind to the switches and…

Q: After the initial Actualization of the Cit+ phenotype, there was another alteration to the A-3…

A: Bacteria are dynamically evolving microbes. Various experiments suggest the evolution process of…

Q: Cellular reprogramming and induced pluripotent stem cells have allowed scientists to model various…

A: Pluripotent stem cells are the cells that can be developed into any cell in the body. The stem cells…

Q: seems that the expert only addressed the background of prorooncogen and the impact of Ras causing…

A: Protooncogenes are the genes that form the proteins that are responsible for cell division and cell…

Q: . a. Mice engineered to block expression of the geneencoding the telomerase protein age at a…

A: Telomerase is an enzyme that is essential for the replication of chromosomal ends. It is a…

Q: Propose a strategy to prevent HIF-alpha signaling in the TME. What do you think would happen in a…

A: The oxygen-sensitive transcriptional activator HIF-1 (hypoxia-inducible factor-1) is an important…

Q: Researchers have successfully used gene therapy toameliorate some human genetic diseases by adding…

A: Gene therapy is a process in which normal copies of genes are introduced into cells, where they can…

Q: Which of the following classes of oncogenes would likely be druggable with a small molecule (select…

A: Oncogenes are genes that have the potential to cause cancer. They can be found in normal cells and…

Q: A graduate student studying yfgA expression in the liver and heart performs an RNA-seq experiment.…

A: In order for a gene to produce functional gene products, such as proteins or non-coding RNA, and…

Q: In unit 1 we learned about the CFTR gene that codes for a chloride channel that does not function…

A: Cystic Fibrosis (CF) is a genetic disorder that is caused by mutations in the CFTR gene. This gene…

Q: Imagine this scenario: In E.coli the Operon X encodes for Proteins Y, X and Z. Proteins Y, X and Z…

A: Introduction  The lac operon is a group of genes in bacteria that are regulated as a unit and are…

Q: Suppose you had a bacteriophage λ in which the gene encoding the cro protein had been mutated, so…

A: The mutation alters allele frequencies by constantly introducing new alleles, which can be…

Q: You are investigating the activity of different cadherins in cells. You use recombinant DNA…

A: The proteins in transmembrane that is useful for cell-cell adhesion. It plays a main role in…

Q: In immediate-early transcription of the phage genome, the N protein works as an antiterminator to…

A: Lambda phage is a bacteriophage which can enter either the lytic or lysogenic cycle. The…

Q: Which of the following statements is not true of both the LacI and TrpR repressor proteins?a) an…

A: The objective of the question is to identify the statement that is not true for both LacI and TrpR…

Q: E. coli has five genes that code for enzymes that make tryptophan. These genes are regulated by a…

A: When a group of related genes exist under the control of a single promoter, it is referred to as an…

Q: graduate student wants to isolate cells from a patient and grow them perpetually in culture to study…

A: The correct answers are as follows- A. Telomerase C. MDM2  A graduate student wants to isolate cells…

Q: 3). Consider the four mutations (i-iv) described below: i. One of the mutations causing cystic…

A: A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur…

Q: Researchers have identified a mutation in the LMNA gene, which encodes some of the pro- teins in the…

A: The intermediate filament proteins lamins A and C are encoded by the LMNA gene, which is found on…

Q: How does reverse methylation affect gene expression? Select one: o a. The gene is turned off, but…

A: Hello. Since your question has multiple parts, we will solve first question for you. If you want…

Q: Give typing answer with explanation and conclusion    a) List three eukaryotic gene expression…

A: Gene expression is the manifestation of the effects of a gene by the production of the particular…

Q: The protein NK2 is a transcriptional regulator that functions both as a repressor and activator. To…

A: A regulatory protein regulates the expression of a gene by binding with that gene through its DNA…

Q: ptoph had a mutation on the repressor, not allowing it to bind with tryptophan. The repressor is…

A: Operons are proteins encoded together as a block that performs specific functions and are involved…

Q: E. coli has five genes that code for enzymes that make tryptophan. These genes are regulated by a…

A: Tryptophan operon found in E.coli and some other bacteria. It is group of genes which encodes for…

Q: The ability to selectively modify the genome in the mouse has revolutionized mouse genetics. Outline…

A: Molecular biology's applications include the development of new protein products, illness prevention…

Q: IPTG Absent IPTG Present B-Galactosidase Permease B- Permease Galactoßsidase + O+ z+ Y+ + IS ot z+…

A: Lac operon is the segment of DNA which consists of regulatory gene (I), promoter gene (P), operator…

Q: The activity provides you with a version of the NGF pathway, an example of a RTK. All of the…

A: The given diagram showing Ras - MAP kinase pathway :-

Q: Look at the structures and predict the type of inhibition (i.e. competitive or non-competitive)…

A: Competitive inhibitor is a structural analogue of the substrate and competes for active site of…

Q: Why are mutations in the spike protein of special interest in regard to vaccine evasion? O Because…

A: The covid-19 pandemic has shook the entire world. The infectivity of the virus strain is of much…

Q: Create a cloning approach that will allow the expression of the SARS-CoV 2 nucleoprotein (NP) in…

A: A gene is a distinct unit of genetic information that is necessary for the creation of a…

Q: Which of the candidate genes would be good targets to develop potential therapeutics using SİRNA…

A: According to the question, we have to mention which of the candidate genes would be good targets to…

Q: Which of the following steps are correct about multistep tumorigenesis (select all that apply)?…

A: When a normal cell undergoes uncontrolled differentiation and division it causes tumor cells. It is…

Q: You work for a large biotechnology company that is studying viruses, vaccines, and small molecule…

A: There are a few important points that should be kept in mind : Viruses are simple, noncellular and…

Q: For the lac operon, when glucose is absent and lactose is present. CAMP-CAP is bound to the promoter…

A: The lac operon is a genetic regulatory system in bacteria that controls the expression of genes…

Q: 6. Suppose a particular gene is required for early development and also later for development of a…

A: ANSWER;- The Gal4 (galactose) gene articulation is directed by Gal80. The Gal4 gene protein…

Q: According to the research article: “Telomerase Modulates Wnt Signalling by Association with Target…

A: Introduction  Telomerase is an enzyme that is responsible for maintaining the length and stability…

Q: Wilms tumor 1, or nephroblastoma, is caused by mutations in the WT1 gene, which encodes a…

A: Molecular biology is an emerging field which focuses on the molecular basis of all biological…

Q: The TBX20 transcription factor is important for the developmentof heart tissue. Deletion of the…

A: T-box transcription factor Tbx20 gene in mice is essential for prenatal cardiomyocyte proliferation…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.