Zeb1 encodes a transcription factor that activates expression of genes that help cells migrate (move to different parts of the body) during embryogenesis. Zeb1 is not expressed in most adult tissues, but can undergo a gain of function mutation in some tumors. Which change is likely to result from a gain of function mutation in Zeb1? a) sustaining proliferative signalling O b) activating invasion and metastasis O c) deregulating cellular energetics O d) resisting cell death

Zeb1 encodes a transcription factor that activates expression of genes that help cells migrate (move to different parts of the body) during embryogenesis. Zeb1 is not expressed in most adult tissues, but can undergo a gain of function mutation in some tumors. Which change is likely to result from a gain of function mutation in Zeb1? a) sustaining proliferative signalling O b) activating invasion and metastasis O c) deregulating cellular energetics O d) resisting cell death

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 9QP: What is the difference between a proto-oncogene and a tumor-suppressor gene?

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Concept explainers

Cell Signaling

It allows cells to perform various cellular activities, coordinate, and interact with other cells. All cells of an organism receive signals from their environments and respond accordingly. Even the unicellular eukaryotes receive signals secreted by other cells and respond. In the case of yeast, mating takes place by signaling between the yeast cells. Communication by cell signaling in a multicellular organism has become a vast and important part of various fields of biology.

Question

Zeb1 encodes a transcription factor that activates expression of genes that help cells
migrate (move to different parts of the body) during embryogenesis. Zeb1 is not
expressed in most adult tissues, but can undergo a gain of function mutation in some
tumors. Which change is likely to result from a gain of function mutation in Zeb1?
a) sustaining proliferative signalling
b) activating invasion and metastasis
O c) deregulating cellular energetics
O d) resisting cell death

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