Researchers have found that a certain signal transduction pathway, illustrated in the figure below, may be responsible for the development of cancer in pancreatic cells. In normal pancreatic cells, where the pathway remains inactive, a membrane-bound receptor called Ptc inhibits a downstream protein known as Smo. The inhibition of Smo blocks the activa- tion of a complex of proteins known as the HSC, which results in the cleaving of one of its proteins called Ci. The cleaving of Ci, in turn, prevents the pathway from initiating the syn- thesis of division-facilitating enzymes. Ptc B Smo с inhibition D HSC Ci cleavage A model of a Ptc signal transduction pathway under normal conditions. cell division not initiated A certain protein called the Hedgehog protein (Hh) is found to activate this signal transduction pathway and trigger uninterruptable cell division. Which of the following describes the most plausible mechanism by which Hh triggers uninterruptable cell division? Hh binds to Ptc and inhibits the functioning of Ptc. cytosol Hh binds to Ptc and inhibits the activation of the HSC. Hh diffuses through the cell membrane and activates Smo Hh binds to Ptc and causes it to catalyze a reaction that uncleaves C.
Researchers have found that a certain signal transduction pathway, illustrated in the figure below, may be responsible for the development of cancer in pancreatic cells. In normal pancreatic cells, where the pathway remains inactive, a membrane-bound receptor called Ptc inhibits a downstream protein known as Smo. The inhibition of Smo blocks the activa- tion of a complex of proteins known as the HSC, which results in the cleaving of one of its proteins called Ci. The cleaving of Ci, in turn, prevents the pathway from initiating the syn- thesis of division-facilitating enzymes. Ptc B Smo с inhibition D HSC Ci cleavage A model of a Ptc signal transduction pathway under normal conditions. cell division not initiated A certain protein called the Hedgehog protein (Hh) is found to activate this signal transduction pathway and trigger uninterruptable cell division. Which of the following describes the most plausible mechanism by which Hh triggers uninterruptable cell division? Hh binds to Ptc and inhibits the functioning of Ptc. cytosol Hh binds to Ptc and inhibits the activation of the HSC. Hh diffuses through the cell membrane and activates Smo Hh binds to Ptc and causes it to catalyze a reaction that uncleaves C.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
Related questions
Question
**Diagram Explanation:**
The diagram is labeled "A model of a Ptc signal transduction pathway under normal conditions." It illustrates a pathway starting with "Ptc inhibition" which affects "Smo." Below "Smo," there is "HSC," followed by an arrow labeled "Ci cleavage," leading to a statement "cell division not initiated." The pathway shows the inhibition and sequential processes leading to the non-initiation of cell division.
---
A certain protein called the Hedgehog protein (Hh) is found to activate this signal transduction pathway and trigger uninterruptable cell division.
Which of the following describes the most plausible mechanism by which Hh triggers uninterruptable cell division?
A. Hh binds to Ptc and inhibits the functioning of Ptc.
B. Hh binds to Ptc and inhibits the activation of the HSC.
C. Hh diffuses through the cell membrane and activates Smo.
D. Hh binds to Ptc and causes it to catalyze a reaction that uncleaves Ci.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F42dff072-7d42-411c-b912-034f8f72c397%2Fdfc5c763-085d-4cc4-885d-5b9fda0f0c2c%2Fczho8m_processed.png&w=3840&q=75)
Transcribed Image Text:Researchers have found that a certain signal transduction pathway, illustrated in the figure below, may be responsible for the development of cancer in pancreatic cells. In normal pancreatic cells, where the pathway remains inactive, a membrane-bound receptor called Ptc inhibits a downstream protein known as Smo. The inhibition of Smo blocks the activation of a complex of proteins known as the HSC, which results in the cleaving of one of its proteins called Ci. The cleaving of Ci, in turn, prevents the pathway from initiating the synthesis of division-facilitating enzymes.
**Diagram Explanation:**
The diagram is labeled "A model of a Ptc signal transduction pathway under normal conditions." It illustrates a pathway starting with "Ptc inhibition" which affects "Smo." Below "Smo," there is "HSC," followed by an arrow labeled "Ci cleavage," leading to a statement "cell division not initiated." The pathway shows the inhibition and sequential processes leading to the non-initiation of cell division.
---
A certain protein called the Hedgehog protein (Hh) is found to activate this signal transduction pathway and trigger uninterruptable cell division.
Which of the following describes the most plausible mechanism by which Hh triggers uninterruptable cell division?
A. Hh binds to Ptc and inhibits the functioning of Ptc.
B. Hh binds to Ptc and inhibits the activation of the HSC.
C. Hh diffuses through the cell membrane and activates Smo.
D. Hh binds to Ptc and causes it to catalyze a reaction that uncleaves Ci.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education