In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) gene in chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normal teeth (d). This condition has been found to be associated with another genetic condition, Osteogenesis imperfecta, characterized by having brittle bones. One type of this disorder occurs when two copies of the recessive allele (c) for collagen type I (COL1A1) gene are present in an individual's chromosome 17. A man with normal teeth and who exhibits a mild case of Osteogenesis imperfecta (Ol) was born to a father who has discolored teeth and a mother who has normal teeth. Both the man's father and mother do not manifest Ol. What is the genotype of... a. a.1. the man's father? a.2. the man's mother? b. If this man in (a) would marry, what should be the genotype of his wife in order that none of their future children will manifest any of the conditions? Support your answer by showing the cross.

In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) gene in chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normal teeth (d). This condition has been found to be associated with another genetic condition, Osteogenesis imperfecta, characterized by having brittle bones. One type of this disorder occurs when two copies of the recessive allele (c) for collagen type I (COL1A1) gene are present in an individual's chromosome 17. A man with normal teeth and who exhibits a mild case of Osteogenesis imperfecta (Ol) was born to a father who has discolored teeth and a mother who has normal teeth. Both the man's father and mother do not manifest Ol. What is the genotype of... a. a.1. the man's father? a.2. the man's mother? b. If this man in (a) would marry, what should be the genotype of his wife in order that none of their future children will manifest any of the conditions? Support your answer by showing the cross.

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Description: In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) genein chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normalteeth (d). This condition has been found to

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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We often speak of diseases such as phenylketonuria (PKU) andachondroplasia as having a genetic basis. Explain whether the followingstatements are accurate with regard to the genetic basis ofany human disease (not just PKU and achondroplasia).A. An individual must inherit two copies of a mutant allele to havedisease symptoms.B. A genetic predisposition means that an individual has inheritedone or more alleles that make it more likely that she or he willdevelop disease symptoms than other individuals in a populationwill.C. A genetic predisposition to develop a disease may be passedfrom parents to offspring.D. The genetic basis for a disease is always more important thanthe environment.
Ehler-Danlos syndrome is a rare disorder caused by a mutation ina gene that encodes a protein called collagen (type 3 A1). Collagenis found in the extracellular matrix that plays an important role inthe formation of skin, joints, and other connective tissues. Peoplewith Ehler-Danlos syndrome have extraordinarily flexible skin andvery loose joints. The following pedigree contains several individualsaffected with this syndrome, shown with black symbols. Basedon this pedigree, does the syndrome follow autosomal recessive,autosomal dominant, X-linked recessive, or X-linked dominantinheritance? Explain your reasoning.
In retinoblastoma, a mutation in one allele of the RB1 tumorsuppressorgene can be inherited from the germ line, causingan autosomal dominant predisposition to the developmentof eye tumors. To develop tumors, a somatic mutation in thesecond copy of the RB1 gene is necessary, indicating that themutation itself acts as a recessive trait. Given that the firstmutation can be inherited, in what ways can a second mutationalevent occur?
In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) gene in chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normal teeth (d). This condition has been found to be associated with another genetic condition, Osteogenesis imperfecta, characterized by having brittle bones. One type of this disorder occurs when two copies of the recessive allele (c) for collagen type I (COLIA1) gene are present in an individual's chromosome 17. 2. A man with normal teeth and who exhibits a mild case of Osteogenesis imperfecta (Ol) was born to a father who has discolored teeth and a mother who has normal teeth. Both the man's father and mother do not manifest Oi. What is the genotype of... a.1. the man's father? a.2. the man's mother? a. b. If this man in (a) would marry, what should be the genotype of his wife in order that none of their future children will manifest any of the conditions? Support your answer by…
In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) gene in chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normal teeth (d). This condition has been found to be associated with another genetic condition, Osteogenesis imperfecta, characterized by having brittle bones. One type of this disorder occurs when two copies of the recessive allele (c) for collagen type I (COL1A1) gene are present in an individuaľ's chromosome 17. a. A man with normal teeth and who exhibits a mild case of Osteogenesis imperfecta (OI) was born to a father who has discolored teeth and a mother who has normal teeth. Both the man's father and mother do not manifest Ol. What is the genotype of... a.1. the man's father? a.2. the man's mother? b. If this man in (a) would marry, what should be the genotype of his wife in order that none of their future children will manifest any of the conditions? Support your answer by showing…
17
Lesch-Nyhan syndrome is due to a mutation in a gene that encodesa protein called hypoxanthine-guanine phosphoribosyltransferase(HPRT). HPRT is an enzyme that functions in purine metabolism.People afflicted with this syndrome have severe neurodegenerationand loss of motor control. The pedigree below contains severalindividuals with Lesch-Nyhan syndrome, shown with blacksymbols. Based on this pedigree, does this syndrome appearto be inherited by an autosomal recessive, autosomal dominant,X-linked recessive, or X-linked dominant pattern? Explainyour reasoning.
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Junctional epidermolysis bullosa (JEB) is a severe skin disorder that results in blisters over the entire body. The disorder is caused by autosomal recessive mutations at any one of three loci that help to encode laminin 5, a major component in the dermal–epidermal basement membrane. Leena Pulkkinen and colleagues described a male newborn who was born with JEB and died at 2 months of age (L. Pulkkinen et al. 1997. American Journal of Human Genetics 61:611–619); the child had healthy, unrelated parents. Chromosome analysis revealed that the infant had 46 normal-appearing chromosomes. Analysis of DNA showed that his mother was heterozygous for a JEB-causing allele at the LAMB3 locus, which is on chromosome 1. The father had two normal alleles at this locus. DNA fingerprinting demonstrated that the male assumed to be the father had, in fact, conceived the child. Q. Assuming that no new mutations occurred in this family, explain the presence of an autosomal recessive disease in the child…
Junctional epidermolysis bullosa (JEB) is a severe skin disorder that results in blisters over the entire body. The disorder is caused by autosomal recessive mutations at any one of three loci that help to encode laminin 5, a major component in the dermal–epidermal basement membrane. Leena Pulkkinen and colleagues described a male newborn who was born with JEB and died at 2 months of age (L. Pulkkinen et al. 1997. American Journal of Human Genetics 61:611–619); the child had healthy, unrelated parents. Chromosome analysis revealed that the infant had 46 normal-appearing chromosomes. Analysis of DNA showed that his mother was heterozygous for a JEB-causing allele at the LAMB3 locus, which is on chromosome 1. The father had two normal alleles at this locus. DNA fingerprinting demonstrated that the male assumed to be the father had, in fact, conceived the child. Q. How might you go about proving your explanation? Assume that a number of genetic markers are available for each chromosome.
The gene controlling ABO blood type and the gene underlying nail-patella syndrome are said to show linkage. What does that mean in terms of their relative locations in the genome? What does it mean in terms of how the two traits are inherited with respect to each other?
Fragile-X syndrome causes the most common form of inherited intellectual disability. What is the chromosomal abnormality associated with this disorder? What is the phenotype of this disorder?