Chapter1: Ready, Set, Go
Section: Chapter Questions
Problem 2MC
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Question
Lesch-Nyhan syndrome is due to a mutation in a gene that encodes
a protein called hypoxanthine-guanine phosphoribosyltransferase
(HPRT). HPRT is an enzyme that functions in purine
People afflicted with this syndrome have severe neurodegeneration
and loss of motor control. The pedigree below contains several
individuals with Lesch-Nyhan syndrome, shown with black
symbols. Based on this pedigree, does this syndrome appear
to be inherited by an autosomal recessive, autosomal dominant,
X-linked recessive, or X-linked dominant pattern? Explain
your reasoning.

Transcribed Image Text:I-1
I-2
П-1
II-2
П-3
П-4
П-5
Il-6
Ш-1
Ш-2
III -3
Ш-4
III -5
Ш-6
III-7
III-8
IV-1
IV-2
IV-3
IV-4
IV-5
IV-6
IV-7
IV-8
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