Below is a pedigree chart for a family that has a history of Alkaptonuria.   Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications.  Given this pedigree answer the following questions.   Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3?  If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype?  Why or why not?

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A: A pedigree helps us to determine the inheritance of a trait across generations in a family.

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Q: 1 2 II 2 3 4 5 6 7 8 III 1 2 3 4 5 6 7 8 9

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Q: this disorder? (Is it autosomal dominant? Autosomal recessive? X-linked dominant? X-linked…

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A:

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A: Pedigree is defined as the family representation for a particular trait.

Q: karyotype is an important clinical method for diagnosing genetic disorders. Explain why it is useful…

A: A karyotype can be defined as a photograph of total chromosomes in a human body. It can be also said…

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A: This is an autosomal recessive trait.

Inheritance and Mendelian Genetics

Inheritance means the passing of traits to offspring from parents. These traits could be passed either through asexual reproduction or sexual reproduction. The offspring receives the genetic material from the parents. Mendelian inheritance is a certain biological inheritance that follows the rules and principles laid down by Gregor Mendel in 1865. The initial hypothesis was considered wrong, but other inheritance theories modified the concept of inheritance and thus genetics.