The attached image is a pedigree of a family with a history of sickle cell anemia (the individuals with the filled-in symbols have the disease and no new mutations are occurring in any individual). Sickle cell anemia is inherited in an autosomal recessive manner. What is the probability that the individual with the question mark (?) will get the disease? a) 1/4 b) 1/2 c) 2/3 d) 1
The attached image is a pedigree of a family with a history of sickle cell anemia (the individuals with the filled-in symbols have the disease and no new mutations are occurring in any individual). Sickle cell anemia is inherited in an autosomal recessive manner. What is the probability that the individual with the question mark (?) will get the disease?
a) 1/4
b) 1/2
c) 2/3
d) 1
Sickle cell anemia is a genetic condition caused by a mutation in the gene that codes for hemoglobin. The condition is characterized by sickle-shaped red blood cells with a reduced ability to carry oxygen.
The mutation in the beta-globin gene results in the formation of beta-hemoglobulin peptides with a valine residue in the 6th position instead of glutamic acid. In nucleotide, the adenine nucleotide is replaced by a thymine nucleotide.
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