Huntington disease is a rare dominant disorder that causes neurodegeneration later in life. In a homozygous state, the dominant allele is lethal.  A man in his thirties, who already has three children, discovers that his mother has Huntington disease though his father is unaffected. What are the following probabilities? a) The man in his thirties will develop Huntington disease. b) His first child will develop Huntington disease. c) Any one out of three of his children will develop Huntington disease.

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A: 50 percent chances.

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Inheritance and Mendelian Genetics

Inheritance means the passing of traits to offspring from parents. These traits could be passed either through asexual reproduction or sexual reproduction. The offspring receives the genetic material from the parents. Mendelian inheritance is a certain biological inheritance that follows the rules and principles laid down by Gregor Mendel in 1865. The initial hypothesis was considered wrong, but other inheritance theories modified the concept of inheritance and thus genetics.