nheritance of one mutant allele of BRCA1 is associated with 70-80% lifetime risk of developing breast cancer in females. How is this possible? Select all that apply. The loss of the mutant chromosome during mitosis A point mutation in the allele of BRCA1 inherited from the normal parent Repair of the heteroduplex region containing a mismatch between the normal DNA strand and the mutant DNA strand Nondisjunction of the normal chromosome during mitosis A deletion of the gene copy inherited from the affected parent Mitotic recombination in the region between the BRCA1 gene and the centromere of the chromosome
BRCA1 is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 protein serves as a key enzyme in repairing DNA double-strand breaks. More than 800 mutations in the BRCA1 are clinically significant. This collection of mutations include missense mutations, small deletions, and large rearrangements that result in a protein with reduced function or no protein product.
Inheritance of one mutant allele of BRCA1 is associated with 70-80% lifetime risk of developing breast cancer in females. How is this possible?
Select all that apply.
A point mutation in the allele of BRCA1 inherited from the normal parent
Mitotic recombination in the region between the BRCA1 gene and the centromere of the chromosome carrying BRCA1
Trending now
This is a popular solution!
Step by step
Solved in 2 steps