Answered: nheritance of one mutant allele of…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

BRCA1 is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 protein serves as a key enzyme in repairing DNA double-strand breaks. More than 800 mutations in the BRCA1 are clinically significant. This collection of mutations include missense mutations, small deletions, and large rearrangements that result in a protein with reduced function or no protein product.

Inheritance of one mutant allele of BRCA1 is associated with 70-80% lifetime risk of developing breast cancer in females. How is this possible?

Select all that apply.

The loss of the mutant chromosome during mitosis

A point mutation in the allele of BRCA1 inherited from the normal parent

Repair of the heteroduplex region containing a mismatch between the normal DNA strand and the mutant DNA strand

Nondisjunction of the normal chromosome during mitosis

A deletion of the gene copy inherited from the affected parent

Mitotic recombination in the region between the BRCA1 gene and the centromere of the chromosome carrying BRCA1

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