Neurofibromas are tumors arising from Schwann cells of the nerve sheath surrounding peripheral nerves. 90% of people who get a neurofibroma just get one tumor, and have no family history of this tumor type. However some individuals get a large number of these tumors over time; this condition is called neurofibromatosis and is inherited as an autosomal dominant trait determined by a single gene. The gene involved is NF1, and encodes a protein called neurofibromin (NF1). The wild-type (normal function) version of NF1 protein downregulates the activity of Ras by promoting the conversion from the GTP- bound (active) form into the GDP-found (inactive) form. Loss of function mutations in NF1 are driver mutations in neurofibroma. Which of the following terms correctly describes the wild type version of the NF1 gene? Oncogene Tumor suppressor gene Proto-oncogene
Neurofibromas are tumors arising from Schwann cells of the nerve sheath surrounding peripheral nerves. 90% of people who get a neurofibroma just get one tumor, and have no family history of this tumor type. However some individuals get a large number of these tumors over time; this condition is called neurofibromatosis and is inherited as an autosomal dominant trait determined by a single gene. The gene involved is NF1, and encodes a protein called neurofibromin (NF1). The wild-type (normal function) version of NF1 protein downregulates the activity of Ras by promoting the conversion from the GTP- bound (active) form into the GDP-found (inactive) form. Loss of function mutations in NF1 are driver mutations in neurofibroma. Which of the following terms correctly describes the wild type version of the NF1 gene? Oncogene Tumor suppressor gene Proto-oncogene
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
Related questions
Topic Video
Question
17
Transcribed Image Text:Neurofibromas are tumors arising from Schwann cells of the nerve sheath
surrounding peripheral nerves. 90% of people who get a neurofibroma just get
one tumor, and have no family history of this tumor type. However some
individuals get a large number of these tumors over time; this condition is called
neurofibromatosis and is inherited as an autosomal dominant trait determined
by a single gene. The gene involved is NF1, and encodes a protein called
neurofibromin (NF1). The wild-type (normal function) version of NF1 protein
downregulates the activity of Ras by promoting the conversion from the GTP-
bound (active) form into the GDP-found (inactive) form. Loss of function
mutations in NF1 are driver mutations in neurofibroma.
Which of the following terms correctly describes the wild type version of the
NF1 gene?
Oncogene
Tumor suppressor gene
Proto-oncogene
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 3 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education