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If provided with a DNA sequence, you should be able to identify where transcription will start; which regions are introns; where the start and stop of translation will occur; as well as what the amino acid sequence of the encoded protein will be. Determining the tertiary structure of a protein is much more challenging however, requiring laborious techniques such as X-ray crystallography or cryo-electron microscopy. Advances in AI protein structure prediction methods such as Alpha Fold2, now make it much easier to visualise protein structures based on the amino acid sequence. Consider the protein structures shown below for NLR protein A and B. Assess the quality of the AlphaFold predictions, by comparing it to the protein structures as determined by Cryo-electron microscopy. NLR protein B NLR protein A Figure 1: Protein structure as determined by Cryo- electron microscopy. Figure 2: AlphaFold2 prediction of the protein structure. Figure 3: The two protein structures superimposed onto each other.

If provided with a DNA sequence, you should be able to identify where transcription will start; which regions are introns; where the start and stop of translation will occur; as well as what the amino acid sequence of the encoded protein will be. Determining the tertiary structure of a protein is much more challenging however, requiring laborious techniques such as X-ray crystallography or cryo-electron microscopy. Advances in AI protein structure prediction methods such as Alpha Fold2, now make it much easier to visualise protein structures based on the amino acid sequence. Consider the protein structures shown below for NLR protein A and B. Assess the quality of the AlphaFold predictions, by comparing it to the protein structures as determined by Cryo-electron microscopy. NLR protein B NLR protein A Figure 1: Protein structure as determined by Cryo- electron microscopy. Figure 2: AlphaFold2 prediction of the protein structure. Figure 3: The two protein structures superimposed onto each other.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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If provided with a DNA sequence, you should be able to identify where transcription will start; which regions are introns; where the start and stop of translation will occur; as well as what the amino acid sequence of the encoded protein will be. Determining the tertiary structure of a protein is much more challenging however, requiring laborious techniques such as X-ray crystallography or cryo-electron microscopy. Advances in AI protein structure prediction methods such as Alpha Fold2, now make it much easier to visualise protein structures based on the amino acid sequence. Consider the protein structures shown below for NLR protein A and B. Assess the quality of the AlphaFold predictions, by comparing it to the protein structures as determined by Cryo-electron microscopy.
Transcribed Image Text:If provided with a DNA sequence, you should be able to identify where transcription will start; which regions are introns; where the start and stop of translation will occur; as well as what the amino acid sequence of the encoded protein will be. Determining the tertiary structure of a protein is much more challenging however, requiring laborious techniques such as X-ray crystallography or cryo-electron microscopy. Advances in AI protein structure prediction methods such as Alpha Fold2, now make it much easier to visualise protein structures based on the amino acid sequence. Consider the protein structures shown below for NLR protein A and B. Assess the quality of the AlphaFold predictions, by comparing it to the protein structures as determined by Cryo-electron microscopy.
NLR protein B NLR protein A Figure 1: Protein structure as determined by Cryo- electron microscopy. Figure 2: AlphaFold2 prediction of the protein structure. Figure 3: The two protein structures superimposed onto each other.
Transcribed Image Text:NLR protein B NLR protein A Figure 1: Protein structure as determined by Cryo- electron microscopy. Figure 2: AlphaFold2 prediction of the protein structure. Figure 3: The two protein structures superimposed onto each other.
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