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Figure out the mutation. You will need the codon table for this question. WT genomic sequence of a portion of the ORF for a eukaryotic gene and matching amino acid sequence of that portion of its gene product. АТА СTG CGC теT AGA CTC ТAT GCG TCT GAG TCT ACG Ile Val Arg Cys Arg Leu Tyr Ala Ser Glu Ser Thr t is found that has the following protein sequence: lle Val Arg Cys Arg Stop. What is the likely mutation?

Figure out the mutation. You will need the codon table for this question. WT genomic sequence of a portion of the ORF for a eukaryotic gene and matching amino acid sequence of that portion of its gene product. АТА СTG CGC теT AGA CTC ТAT GCG TCT GAG TCT ACG Ile Val Arg Cys Arg Leu Tyr Ala Ser Glu Ser Thr t is found that has the following protein sequence: lle Val Arg Cys Arg Stop. What is the likely mutation?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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### Educational Resource: Understanding Mutations in Genetic Sequences #### Task: Figure out the mutation in a given genetic sequence. You will need the codon table for this exercise. #### Wild-Type (WT) Genomic Sequence: This is a portion of the open reading frame (ORF) for a eukaryotic gene, alongside the corresponding amino acid sequence of that portion. **Nucleotide Sequence:** ``` ATA GTG CGC TGT AGA CTC TAT GCG TCT GAG TCT ACG ``` **Amino Acid Sequence:** ``` Ile Val Arg Cys Arg Leu Tyr Ala Ser Glu Ser Thr ``` #### Mutant Analysis: A mutant is found with the following protein sequence: ``` Ile Val Arg Cys Arg Leu Cys Val Stop ``` Determine the likely mutation that leads to this change. #### Mutation Options: Choose one of the following: - A13 -> T - A15 -> T - C16, T17, C18 -> del - T17, C18 -> del - Between T17 and C18 -> insert GG - Digital copy: ATA GTG CGC TGT AGA CTC TAT GCG TCT GAG TCT ACG ### Explanation of Choices: These options represent possible point mutations or deletions/insertions in the nucleotide sequence. By comparing these modifications to the wild-type sequence, and cross-referencing the resulting codons with a codon table, one can determine the mutation responsible for the altered protein sequence. #### Conclusion: Determining the exact mutation involves analyzing the nucleotide changes and their impact on the amino acid sequence, identifying where and how the mutation results in a premature stop codon or other alterations to the protein structure.
Transcribed Image Text:### Educational Resource: Understanding Mutations in Genetic Sequences #### Task: Figure out the mutation in a given genetic sequence. You will need the codon table for this exercise. #### Wild-Type (WT) Genomic Sequence: This is a portion of the open reading frame (ORF) for a eukaryotic gene, alongside the corresponding amino acid sequence of that portion. **Nucleotide Sequence:** ``` ATA GTG CGC TGT AGA CTC TAT GCG TCT GAG TCT ACG ``` **Amino Acid Sequence:** ``` Ile Val Arg Cys Arg Leu Tyr Ala Ser Glu Ser Thr ``` #### Mutant Analysis: A mutant is found with the following protein sequence: ``` Ile Val Arg Cys Arg Leu Cys Val Stop ``` Determine the likely mutation that leads to this change. #### Mutation Options: Choose one of the following: - A13 -> T - A15 -> T - C16, T17, C18 -> del - T17, C18 -> del - Between T17 and C18 -> insert GG - Digital copy: ATA GTG CGC TGT AGA CTC TAT GCG TCT GAG TCT ACG ### Explanation of Choices: These options represent possible point mutations or deletions/insertions in the nucleotide sequence. By comparing these modifications to the wild-type sequence, and cross-referencing the resulting codons with a codon table, one can determine the mutation responsible for the altered protein sequence. #### Conclusion: Determining the exact mutation involves analyzing the nucleotide changes and their impact on the amino acid sequence, identifying where and how the mutation results in a premature stop codon or other alterations to the protein structure.
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