A mutant is found that has the following protein sequence: Met Gly Thr Leu Arg Gly. What is the likely mutation?

Q: When human hemoglobin undergoes a mutation, the mutant protein usually does not replace all of the…

A: The cytosol of red blood cells contains the oxygen-carrying globular protein hemoglobin, which is…

Q: Draw a tripeptide only containing Alanine

A: Amino acids are the building blocks of proteins which are composed of amino group (NH3+), carboxyl…

Q: A gene contains 30% thymine. What is the percentage of pyrimidines present in this segment? Explain.

A: Purines and pyrimidines are chemical molecules that play a role in the production of DNA and RNA and…

Q: Sickle cell anemia is caused by a point mutation in the β-globin chain of hemoglobin. Glutamic acid…

A: Introduction : Haemoglobin is a tetrameric proteinmade up of 2 alpha subunits and 2 beta subunits…

Q: Placenta ... a) ... develops from trophoblast cells. b) ... develops from embryoblast cells. c)…

A: Pregnancy occurs when the male gamete sperm fuses and fertilizes with the female egg that is…

Q: Calculate the pI for the following tri-peptide: Glu-Arg-Lys

A: pI or isoelectric point is the pH at which a peptide or molecule is electrically neutral. The pH of…

Q: the peptide (written N-terminal to C-terminal) represented by Ala-Ser-Ala-Tyr the same as the…

A: Ans. Yes, the polypeptide chain of amino acid will be Similarly in structure and function whether it…

Q: n as1 mutant, assign secondary structure and tell how many alpha helices and beta-pleated sheets…

A: Primary Structure: It is defined as a linear sequence of amino acids joined to each other through a…

Q: Why would the mutation Ile -> Asp be likely to destabilize a protein? Why would the mutation Ile…

A: Mutations in proteins' amino acid sequences can have an impact on their stability. Long sequences of…

Q: On average, how many phosphoanhydride bonds (P;-P; bonds) are directly hydrolyzed in the course of…

A: As per the central dogma of molecular biology, genetic information is stored in the DNA. The genetic…

Q: A mutation that changes an alanine to a leucine in the nucleus of a protein leads to a less active…

A: Introduction: Each organism's DNA sequence is unique. Its base-pairs sequence can change from time…

Q: The normal sequence of a protein is: Met – Thr – Lys – His – Ser – Ser ... Mutations of the DNA…

A: In this problem, the normal sequence of a protein is given, and three different protein sequences…

Q: Many blood clotting proteins undergo a post-translational modification in which specific glutamic…

A: Post Translational Modifications (PTM) of such complexity is only observed in eukaryotes and not in…

Q: Which amino acid pair constitutes the hydrophobic patch on sickle cell hemoglobin that results in…

A: Sickle cell disease is caused due to inversion of one base pair (A -> T). Due to which, the sixth…

Q: Why is the position of Cys 58  important in 3GRS(GLUTATHIONE REDUCTASE)? When Cys 58  is mutated to…

A: Dear Students, I have downloaded the PDB ID 3GRS structure from https://www.rcsb.org/ This is the…

Q: В C as1 wild type as1 mutant as1 superimposed A

A: Alpha-helices and beta-sheets are called the secondary structures of the protein. Secondary…

Q: Draw and label the following RNA tetranucleotide: 5’phosphoryl-A-2’O-methyl-C-U-G-3’-phosphate

A: DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) are polynucleotides, i.e., they are polymers…

Q: A normal polypeptide and a mutant of the polypeptide were hydrolyzed by an endopeptidase under the…

A: Chromatography is a useful technique to study the separation of amino acids. Paper chromatography is…

Q: Use the following DNA sequence, and write the resulting messenger RNA sequence

A: When DNA makes it's two copies then this is called replication. When DNA is converted into RNA then…

Q: The SARS-CoV-2 spike protein is heavily glycosylated. What are some of the monosaccharides found in…

A: The spike (S) protein of SARS-CoV-2 mediates the virus binding to the human cells via its…

Q: You could use absorbance at 280nm or colorimetric assays like the Bradford assay or bicinchoninic…

A: There are different methods present to measure the concentration of a given protein.

Q: You have discovered a novel protein that has a pl = 5.5. To study the functional properties of this…

A: pI of protein is directly proportional to the pKa of amino acids.

Clinical Pharmacology

Pharmacology is a discipline of medicine that studies how medications interact with the systems and processes of living organisms, focusing on drug action mechanisms as well as therapeutic and other purposes.