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Dominant mutations in the Akt gene have been identified that lead to gain- of-function phenotypes. In these children, the Akt protein has a E17K mutation, which results in the Akt protein being phosphorylated by PDK1 in the absence of insulin signaling. It is observed in these patients that the GRB2 pathway is also activated in the absence of insulin. Predict two symptoms in these patients resulting from activation of insulin signaling in the absence of insulin. Prefix definitions; hypo= below, hyper = above. 1) Severe fasting hyperglycemia, 2) Abnormal tissue hypergrowth 1) Insulin resistance in muscle, 2) Abnormal tissue hypergrowth 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypogrowth 1) Severe fasting hyperglycemia, 2) Defect in insulin secretion 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypergrowth

Dominant mutations in the Akt gene have been identified that lead to gain- of-function phenotypes. In these children, the Akt protein has a E17K mutation, which results in the Akt protein being phosphorylated by PDK1 in the absence of insulin signaling. It is observed in these patients that the GRB2 pathway is also activated in the absence of insulin. Predict two symptoms in these patients resulting from activation of insulin signaling in the absence of insulin. Prefix definitions; hypo= below, hyper = above. 1) Severe fasting hyperglycemia, 2) Abnormal tissue hypergrowth 1) Insulin resistance in muscle, 2) Abnormal tissue hypergrowth 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypogrowth 1) Severe fasting hyperglycemia, 2) Defect in insulin secretion 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypergrowth

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Dominant mutations in the Akt gene have been identified that lead to gain-of-function phenotypes. In these children, the Akt protein has an E17K mutation, which results in the Akt protein being phosphorylated by PDK1 in the absence of insulin signaling. It is observed in these patients that the GRB2 pathway is also activated in the absence of insulin. Predict two symptoms in these patients resulting from activation of insulin signaling in the absence of insulin. Prefix definitions; hypo = below, hyper = above. - 1) Severe fasting hyperglycemia, 2) Abnormal tissue hypergrowth - 1) Insulin resistance in muscle, 2) Abnormal tissue hypergrowth - 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypogrowth - 1) Severe fasting hyperglycemia, 2) Defect in insulin secretion - 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypergrowth
Transcribed Image Text:Dominant mutations in the Akt gene have been identified that lead to gain-of-function phenotypes. In these children, the Akt protein has an E17K mutation, which results in the Akt protein being phosphorylated by PDK1 in the absence of insulin signaling. It is observed in these patients that the GRB2 pathway is also activated in the absence of insulin. Predict two symptoms in these patients resulting from activation of insulin signaling in the absence of insulin. Prefix definitions; hypo = below, hyper = above. - 1) Severe fasting hyperglycemia, 2) Abnormal tissue hypergrowth - 1) Insulin resistance in muscle, 2) Abnormal tissue hypergrowth - 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypogrowth - 1) Severe fasting hyperglycemia, 2) Defect in insulin secretion - 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypergrowth
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