Below is a primary sequence alignment between the wild-type hemoglobin protein, and the hemoglobin mutant that causes sickle-cell anemia. Please look at the alignment and select the correct answer below. wt_hemoglobin: MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK 60 sickle_cell: MVHLTPVEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK 60 * wt_hemoglobin: VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG 120 sickle_cell: VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG 120 ************** wt_hemoglobin: KEFTPPVQAAYQKVVAGVANALAHKYH 147 sickle_cell: KEFTPPVQAAYQKVVAGVANALAHKYH 147 Answers: A) The observed mutation is a negatively charged to a nonpolar amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold B) The observed mutation is a negatively charged to a polar amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold C) The observed mutation is a positively charged to a nonpolar amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold D) The observed mutation is a nonpolar to a negatively charged amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold E) The observed mutation is a polar uncharged to a nonpolar amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Below is a primary sequence alignment between the wild-type hemoglobin protein, and the hemoglobin mutant that causes sickle-cell anemia. Please look at the alignment and select the correct answer below.

wt_hemoglobin: MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK 60

sickle_cell: MVHLTPVEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK 60

****** *****************************************************

wt_hemoglobin: VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG 120

sickle_cell: VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG 120

************************************************************

wt_hemoglobin: KEFTPPVQAAYQKVVAGVANALAHKYH 147

sickle_cell: KEFTPPVQAAYQKVVAGVANALAHKYH 147

Answers:

A) The observed mutation is a negatively charged to a nonpolar amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold

B) The observed mutation is a negatively charged to a polar amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold

C) The observed mutation is a positively charged to a nonpolar amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold

D) The observed mutation is a nonpolar to a negatively charged amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold

E) The observed mutation is a polar uncharged to a nonpolar amino acid. Such a change dramatically changes the local environment, causing the protein to mis-fold

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