Let’s return to your patient with sickle cell anemia. Below is the RNA sequence from your patient and from her mother. (The ••• represents another 30 nucleotides not written out here). The affected nucleotide is indicated in BOLD.Patient’s RNA: 5’ –CUAUGACAGAGUUC•••CAUUAGCCA – 3’Mother’s RNA: 5’ –CUAUGACAGUGUUC•••CAUUAGCCA – 3’C) Write out the sequence of the normal beta-globin protein (as much as you can given the above info and below genetic code table) and indicate what would be different in the mutant protein. Don't forget your ends! UCATyr UGU CysUGC CysUUUPhePheUCUSerUAUUUCUCSerUACCTyrStop UGA Stop AStop UGG TrpUUUASerLeuUCAUAAUUGLeuUCGSerUAGCUCUCCCUCGU ArgUProProProProCAUCACCAACAGHisHisGlnGlnLeuLeuCUA LeuCUG LeuCCCACGCGCArgCCGA ArgCGG ArgAsn AGU SerAUUAUCAAUA lleAUG Met ACGllelleACUACCACAThrAAUAACAAAThr AAGUAsn AGC SerAGA ArgGThrThrLysALys AGG ArgAla GAUGACAlaAsp GGU GlyGUU ValGCUGCCGUC ValGGUA ValAsp GGC GlyCGCA Ala GAAAlaGluGGA GlyAGUG ValGCGGAGGluGGG GlyGDUAGDUAG

The mutations can change the amino acids coded as the codon changes. The mutations can be silent…

Answered: Let’s return to your patient with…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Let’s return to your patient with sickle cell anemia. Below is the RNA sequence from your patient and from her mother. (The ••• represents another 30 nucleotides not written out here). The affected nucleotide is indicated in BOLD.

Patient’s RNA: 5’ –CUAUGACAGAGUUC•••CAUUAGCCA – 3’

Mother’s RNA: 5’ –CUAUGACAGUGUUC•••CAUUAGCCA – 3’

C) Write out the sequence of the normal beta-globin protein (as much as you can given the above info and below genetic code table) and indicate what would be different in the mutant protein. Don't forget your ends!

U
C
A
Tyr UGU Cys
UGC Cys
UUU
Phe
Phe
UCU
Ser
UAU
UUC
UC
Ser
UAC
C
Tyr
Stop UGA Stop A
Stop UGG Trp
U
UUA
Ser
Leu
UCA
UAA
UUG
Leu
UCG
Ser
UAG
CU
CUC
CCU
CGU Arg
U
Pro
Pro
Pro
Pro
CAU
CAC
CAA
CAG
His
His
Gln
Gln
Leu
Leu
CUA Leu
CUG Leu
C
CCA
CG
CGC
Arg
C
CGA Arg
CGG Arg
Asn AGU Ser
AUU
AUC
A
AUA lle
AUG Met ACG
lle
lle
ACU
ACC
ACA
Thr
AAU
AAC
AAA
Thr AAG
U
Asn AGC Ser
AGA Arg
G
Thr
Thr
Lys
A
Lys AGG Arg
Ala GAU
GAC
Ala
Asp GGU Gly
GUU Val
GCU
GCC
GUC Val
G
GUA Val
Asp GGC Gly
C
GCA Ala GAA
Ala
Glu
GGA Gly
A
GUG Val
GCG
GAG
Glu
GGG Gly
G
DUAG
DUAG

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