Cystic hibros Ife-threatering disease that causes thick, stcky mucus to buid up in areas of the body, inciuding the lungs. are studying CF TR associated with cystic fibrosis in fumans. In the majority of cystic fibrosis patients, the same mutation is seen in the same location on the CFTR gene. A partial DNA sequence, a partial MRNA transoript, and part of the normal polypetide that the makes up the CFTR protein that the CFTR gene codes for are shown in the dagram below. ONA STTA RNA STA Polypeptide A partial DNA sequence, a partiai MRNA transcript, and part of the CFTR polypeptide in a cystic fbrosis patient are shown in the diagram below. DNA 3 TTAO MRNA S Polypeptide Gy A Describe the change in the DNA sequence, the effect on the MRNA, and the effect on the polypeptide. B is this a "true" trameshift mutation? Why or why not? C. Would a single base insertion at the beginning of the gene have a larger or smaller effect on the resulting polypeptide than the CFTR mutation? Explain your answer.
Cystic hibros Ife-threatering disease that causes thick, stcky mucus to buid up in areas of the body, inciuding the lungs. are studying CF TR associated with cystic fibrosis in fumans. In the majority of cystic fibrosis patients, the same mutation is seen in the same location on the CFTR gene. A partial DNA sequence, a partial MRNA transoript, and part of the normal polypetide that the makes up the CFTR protein that the CFTR gene codes for are shown in the dagram below. ONA STTA RNA STA Polypeptide A partial DNA sequence, a partiai MRNA transcript, and part of the CFTR polypeptide in a cystic fbrosis patient are shown in the diagram below. DNA 3 TTAO MRNA S Polypeptide Gy A Describe the change in the DNA sequence, the effect on the MRNA, and the effect on the polypeptide. B is this a "true" trameshift mutation? Why or why not? C. Would a single base insertion at the beginning of the gene have a larger or smaller effect on the resulting polypeptide than the CFTR mutation? Explain your answer.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
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Transcribed Image Text:Cystic fibrosis is a life-threatening disease that causes thick, sticky mucus to build up in areas of the body, including the lungs. Scientists are studying CFTR, the gene
associated with cystic fibrosis in humans. In the majority of cystic fibrosis patients, the same mutation is seen in the same location on the CFTR gene.
A partial DNA sequence, a partial MRNA transcript, and part of the normal polypetide that the makes up the CFTR protsin that the CFTR gene codes for are shown in
the diagram below.
DNA 3
MRNA S
Polypeptide
Gly
A partial DNA sequence, a partial MRNA transcript, and part of the CFTR polypeptide in a cystic fibrosis patient are shown in the diagram belaw.
DNA 3
MRNA 5
Polypeptide
A Describe the change in the DNA sequence, the effect on the MRNA, and the effect on the polypeptide.
Is this a "true" frameshift mutation? Why or why not?
B.
C. Would a single base insertion at the beginning of the gene have a larger or smaller effect on the resulting polypeptide than the CFTR mutation? Explain your
answer.
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