Let’s return to your patient with sickle cell anemia.  Below is the RNA sequence from your patient and from her mother.  (The ••• represents another 30 nucleotides not written out here). The affected nucleotide is indicated in BOLD. Patient’s RNA:  5’ –CUAUGACAGAGUUC•••CAUUAGCCA – 3’ Mother’s RNA: 5’ –CUAUGACAGUGUUC•••CAUUAGCCA – 3’ C)  Write out the sequence of the normal beta-globin protein (as much as you can given the above info and below genetic code table) and indicate what would be different in the mutant protein.  Don't forget you

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Let’s return to your patient with sickle cell anemia.  Below is the RNA sequence from your patient and from her mother.  (The ••• represents another 30 nucleotides not written out here). The affected nucleotide is indicated in BOLD.

Patient’s RNA:  5’ –CUAUGACAGAGUUC•••CAUUAGCCA – 3’

Mother’s RNA: 5’ –CUAUGACAGUGUUC•••CAUUAGCCA – 3’

C)  Write out the sequence of the normal beta-globin protein (as much as you can given the above info and below genetic code table) and indicate what would be different in the mutant protein.  Don't forget your ends!

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