hough one might think that disease alleles and other deleterious mutations would be eliminated from a gene pool over time through negative selection pressures, this is always the case. Describe one of the reasons why disease alleles can continue to be present or even common in a population.
hough one might think that disease alleles and other deleterious mutations would be eliminated from a gene pool over time through negative selection pressures, this is always the case. Describe one of the reasons why disease alleles can continue to be present or even common in a population.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Although one might think that disease alleles and other deleterious mutations would be eliminated from a gene pool over time through negative selection pressures, this is
not always the case. Describe one of the reasons why disease alleles can continue to be present or even common in a population.
Transcribed Image Text:Cystic fibrosis (CF) is an autosomal recessive disorder. Several different individual point mutations in the CFTR gene cause cystic fibrosis. Two of the most common mutations (A
and B) are shown on the diagram below. The lines below the gene represent ASO (allele-specific oligonucleotide) probes and the regions of the gene to which they hybridize. The
"wild type" probe hybridizes to the wild type allele and the "mutant" probe hybridizes to the mutant allele of this gene.
В
CFTR gene
Probe 1 wild type
Probe 3 wild type
Probe 2 mutant
Probe 4 mutant
Five people underwent ASO testing for cystic fibrosis using all four of the probes shown below. The results of this test are shown in the diagram.
#1
#2
#3
# 4
#5
Probe 1
Probe 2
Probe 3
Probe 4
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