(B) Twenty-four vertebrate LDH proteins arranged into a family tree based on their amino acid sequences Cattle LDH-A KEY Diamonds mark branch points where, on the basis of available evidence, gene duplication A forms Pig LDH-A B forms Rabbit LDH-A C forms occurred. Mouse LDH-A Rat LDH-A Human LDH-A Chicken LDH-A Fax LDH-C Human LDH-C Mouse LDH-C Rat LDH-C Dogfish shark LDH-A Lamprey LDH - Kilifish LDH-A Kilifish LDH-B Kilifish LDH-C Xenopus LDH-B Xenapus LDH-C Xenopus LDH-A Duck LDH-B Chicken LDH-B Pig LDH-B Human LDH-B Mouse LDH-B Number of amino acids modified by mutation

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question

It is becoming possible for molecular biologists to synthesize
almost any protein desired. Suppose you use a phylogenetic tree
of modern-day enzymes (e.g., Figure 2.21B) to predict the amino
acid sequence of a now-nonexistent ancestral enzyme form.
What insights might you obtain by synthesizing the ancestral
enzyme protein?

(B) Twenty-four vertebrate LDH proteins arranged into a family tree based
on their amino acid sequences
Cattle LDH-A
KEY
Diamonds mark
branch points where,
on the basis of
available evidence,
gene duplication
A forms
Pig LDH-A
B forms
Rabbit LDH-A
C forms
occurred.
Mouse LDH-A
Rat LDH-A
Human LDH-A
Chicken LDH-A
Fax LDH-C
Human LDH-C
Mouse LDH-C
Rat LDH-C
Dogfish shark LDH-A
Lamprey LDH
- Kilifish LDH-A
Kilifish LDH-B
Kilifish LDH-C
Xenopus LDH-B
Xenapus LDH-C
Xenopus LDH-A
Duck LDH-B
Chicken LDH-B
Pig LDH-B
Human LDH-B
Mouse LDH-B
Number of amino acids modified by mutation
Transcribed Image Text:(B) Twenty-four vertebrate LDH proteins arranged into a family tree based on their amino acid sequences Cattle LDH-A KEY Diamonds mark branch points where, on the basis of available evidence, gene duplication A forms Pig LDH-A B forms Rabbit LDH-A C forms occurred. Mouse LDH-A Rat LDH-A Human LDH-A Chicken LDH-A Fax LDH-C Human LDH-C Mouse LDH-C Rat LDH-C Dogfish shark LDH-A Lamprey LDH - Kilifish LDH-A Kilifish LDH-B Kilifish LDH-C Xenopus LDH-B Xenapus LDH-C Xenopus LDH-A Duck LDH-B Chicken LDH-B Pig LDH-B Human LDH-B Mouse LDH-B Number of amino acids modified by mutation
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