Higashi et al. (1986) found that three critical mutations were found in one of the two genes coding for 21-hydroxylase to render the gene nonfunctional. The following is a partial DNA sequence from one of the 21-hydroxylase genes where one of the three most common mutations occurs. For the following

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.