In the corn snake Pantherophis guttatus, there are several different color variants, including amelanistic snakes whose skin patterns display only red and yellow pigments. The cause of amelanism in these snakes was recently identified as the insertion of a transposable element into an intron in the OCA2 (oculocutaneous albinism) gene. How might the insertion of extra genetic material into an intron lead to a nonfunctional protein? H▾▾ B I A X₂ X² Ω Y <> 66 X
In the corn snake Pantherophis guttatus, there are several different color variants, including amelanistic snakes whose skin patterns display only red and yellow pigments. The cause of amelanism in these snakes was recently identified as the insertion of a transposable element into an intron in the OCA2 (oculocutaneous albinism) gene. How might the insertion of extra genetic material into an intron lead to a nonfunctional protein? H▾▾ B I A X₂ X² Ω Y <> 66 X
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:**Amelanism in Corn Snakes (Pantherophis guttatus)**
In the corn snake Pantherophis guttatus, there are several different color variants, including amelanistic snakes whose skin patterns display only red and yellow pigments. The cause of amelanism in these snakes was recently identified as the insertion of a transposable element into an intron in the OCA2 (oculocutaneous albinism) gene. How might the insertion of extra genetic material into an intron lead to a nonfunctional protein?
### Explanation of Genetic Mutation:
Amelanism is caused by a disruption in the OCA2 gene, which involves the insertion of extra genetic material into an intron. This can potentially interfere with normal gene expression, leading to the production of a nonfunctional protein. The insertion may affect splicing or result in a frame-shift that disrupts the proper coding of proteins.
Expert Solution
Step 1
Introns are non-coding sequences and exons are coding sequences in the gene. Splicing is the process of removal of introns from the gene and joining of exons to produce a mature mRNA. The mature mRNA undergoes translation process to synthesize proteins.
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