Consider the hypothetical serine protease, which shows the specificity pockets. The S, pocket has a glutamic acid in the bottom, the Sz pocket is small and hydrophobic, and the S,' pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave. H. R2 HR Which of the sequences would this protease cleave? O Lys-Ala-Leu Ala-Lys-Leu Leu-Ala-Lys Ala-Leu-Lys Leu-Lys-Ala C=O
Consider the hypothetical serine protease, which shows the specificity pockets. The S, pocket has a glutamic acid in the bottom, the Sz pocket is small and hydrophobic, and the S,' pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave. H. R2 HR Which of the sequences would this protease cleave? O Lys-Ala-Leu Ala-Lys-Leu Leu-Ala-Lys Ala-Leu-Lys Leu-Lys-Ala C=O
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:Consider the hypothetical serine protease, which shows the
specificity pockets. The S, pocket has a glutamic acid in
the bottom, the S, pocket is small and hydrophobic, and the
S,' pocket is deep and hydrophobic. Suggest an amino acid
sequence that this protease would cleave.
HRY
S2
Si
Which of the sequences would this protease cleave?
O Lys-Ala-Leu
O Ala-Lys-Leu
Leu-Ala-Lys
Ala-Leu-Lys
O Leu-Lys-Ala
O Lys-Leu-Ala
C=O
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